Mus musculus Gene: Gnb2l1
Summary
InnateDB Gene IDBG-166211.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gnb2l1
Gene Name guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1
Synonyms AL033335; GB-like; Gnb2-rs1; p205; Rack1;
Species Mus musculus
Ensembl Gene ENSMUSG00000020372
Encoded Proteins
guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] GNB2L1 (RACK1) negatively regulates NFκB activation by interacting with CHUK and IKBKB. The interaction interferes with the recruitment of the IKK complex to TRAF2 .
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204628:
Gene Information
Type Protein coding
Genomic Location Chromosome 11:48800332-48806434
Strand Forward strand
Band B1.2
Transcripts
ENSMUST00000020640 ENSMUSP00000020640
ENSMUST00000142269
ENSMUST00000139959
ENSMUST00000136703
ENSMUST00000125166
ENSMUST00000136849
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 129 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 129 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0008200 ion channel inhibitor activity
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019899 enzyme binding
GO:0019903 protein phosphatase binding
GO:0030292 protein tyrosine kinase inhibitor activity
GO:0030971 receptor tyrosine kinase binding
GO:0042169 SH2 domain binding
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0001934 positive regulation of protein phosphorylation
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007049 cell cycle
GO:0007369 gastrulation
GO:0008104 protein localization
GO:0010629 negative regulation of gene expression
GO:0017148 negative regulation of translation
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030308 negative regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030822 positive regulation of cAMP catabolic process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032464 positive regulation of protein homooligomerization
GO:0032880 regulation of protein localization
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0048511 rhythmic process
GO:0050765 negative regulation of phagocytosis
GO:0051302 regulation of cell division
GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051726 regulation of cell cycle
GO:0051898 negative regulation of protein kinase B signaling
GO:0051901 positive regulation of mitochondrial depolarization
GO:0061099 negative regulation of protein tyrosine kinase activity
GO:0090003 regulation of establishment of protein localization to plasma membrane
GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death
GO:2000114 regulation of establishment of cell polarity
GO:2000543 positive regulation of gastrulation
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0001891 phagocytic cup
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0030425 dendrite
GO:0030496 midbody
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
AndrogenReceptor pathway
TNFalpha pathway
IL3 pathway
IL5 pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Syndecan-2-mediated signaling events
CXCR4-mediated signaling events
TNF receptor signaling pathway
IGF1 pathway
p73 transcription factor network
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
Regulation of Androgen receptor activity
Validated transcriptional targets of deltaNp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.396849
RefSeq NM_008143
OMIM
CCDS CCDS24585
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas