InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gnb2l1

Summary

InnateDB Gene

IDBG-166211.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gnb2l1

Gene Name

guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1

Synonyms

AL033335; GB-like; Gnb2-rs1; p205; Rack1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020372

Encoded Proteins

IDBP-166213

guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24323043

[Homo sapiens] GNB2L1 (RACK1) negatively regulates NFκB activation by interacting with CHUK and IKBKB. The interaction interferes with the recruitment of the IKK complex to TRAF2 .

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204628:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:48800332-48806434

Strand

Forward strand

Band

B1.2

Transcripts

ENSMUST00000020640	ENSMUSP00000020640
ENSMUST00000142269
ENSMUST00000139959
ENSMUST00000136703
ENSMUST00000125166
ENSMUST00000136849

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 129 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	129 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008200	ion channel inhibitor activity
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019899	enzyme binding
GO:0019903	protein phosphatase binding
GO:0030292	protein tyrosine kinase inhibitor activity
GO:0030971	receptor tyrosine kinase binding
GO:0042169	SH2 domain binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0001934	positive regulation of protein phosphorylation
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007049	cell cycle
GO:0007369	gastrulation
GO:0008104	protein localization
GO:0010629	negative regulation of gene expression
GO:0017148	negative regulation of translation
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030308	negative regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0030822	positive regulation of cAMP catabolic process
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032464	positive regulation of protein homooligomerization
GO:0032880	regulation of protein localization
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0048511	rhythmic process
GO:0050765	negative regulation of phagocytosis
GO:0051302	regulation of cell division
GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051726	regulation of cell cycle
GO:0051898	negative regulation of protein kinase B signaling
GO:0051901	positive regulation of mitochondrial depolarization
GO:0061099	negative regulation of protein tyrosine kinase activity
GO:0090003	regulation of establishment of protein localization to plasma membrane
GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death
GO:2000114	regulation of establishment of cell polarity
GO:2000543	positive regulation of gastrulation
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0001891	phagocytic cup
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0030425	dendrite
GO:0030496	midbody
GO:0043025	neuronal cell body
GO:0043204	perikaryon
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome