Mus musculus Gene: Dennd1a
Summary
InnateDB Gene IDBG-166357.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dennd1a
Gene Name DENN/MADD domain containing 1A
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000035392
Encoded Proteins
DENN/MADD domain containing 1A
DENN/MADD domain containing 1A
DENN/MADD domain containing 1A
DENN/MADD domain containing 1A
DENN/MADD domain containing 1A
DENN/MADD domain containing 1A
DENN/MADD domain containing 1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119522:
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:37798991-38287390
Strand Reverse strand
Band B
Transcripts
ENSMUST00000102787 ENSMUSP00000099848
ENSMUST00000136460 ENSMUSP00000115527
ENSMUST00000140552 ENSMUSP00000120998
ENSMUST00000150896 ENSMUSP00000116723
ENSMUST00000130472 ENSMUSP00000119892
ENSMUST00000126889
ENSMUST00000143095 ENSMUSP00000116018
ENSMUST00000142813 ENSMUSP00000116396
ENSMUST00000136116
ENSMUST00000128492
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017112 Rab guanyl-nucleotide exchange factor activity
GO:0017124 SH3 domain binding
Biological Process
GO:0006897 endocytosis
GO:0015031 protein transport
GO:0032313 regulation of Rab GTPase activity
GO:0032483 regulation of Rab protein signal transduction
GO:0032851 positive regulation of Rab GTPase activity
GO:0048488 synaptic vesicle endocytosis
Cellular Component
GO:0030054 cell junction
GO:0030136 clathrin-coated vesicle
GO:0030425 dendrite
GO:0030665 clathrin-coated vesicle membrane
GO:0042734 presynaptic membrane
GO:0043025 neuronal cell body
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.314245
RefSeq NM_146122 XM_006498004 XM_006498005 XM_006498007
OMIM
CCDS CCDS16007
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas