Version 5.4
Mus musculus Gene: Col18a1
Summary
InnateDB Gene IDBG-166544.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Col18a1
Gene Name collagen, type XVIII, alpha 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000001435
Encoded Proteins
IDBP-166546
collagen, type XVIII, alpha 1
IDBP-166548
collagen, type XVIII, alpha 1
IDBP-270939
collagen, type XVIII, alpha 1
IDBP-531908
collagen, type XVIII, alpha 1
IDBP-541445
collagen, type XVIII, alpha 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182871:
This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:77052178-77166548
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000081654 ENSMUSP00000080358
ENSMUST00000072755 ENSMUSP00000072538
ENSMUST00000105409 ENSMUSP00000101049
ENSMUST00000156009 ENSMUSP00000122580
ENSMUST00000149744 ENSMUSP00000116418
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0001886 endothelial cell morphogenesis
GO:0007155 cell adhesion
GO:0008284 positive regulation of cell proliferation
GO:0016055 Wnt signaling pathway
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0042493 response to drug
GO:0051599 response to hydrostatic pressure
GO:2000353 positive regulation of endothelial cell apoptotic process
Cellular Component
GO:0005581 collagen trimer
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000182871
View Gene Order
ENSBTAG00000023907
Not yet available
Pathways
NETPATH
REACTOME
REACT_199045
Collagen formation pathway
REACT_199046
Assembly of collagen fibrils and other multimeric structures pathway
REACT_198984
Collagen biosynthesis and modifying enzymes pathway
REACT_199000
Activation of Matrix Metalloproteinases pathway
REACT_206066
Extracellular matrix organization pathway
REACT_202342
Laminin interactions pathway
REACT_216309
Integrin cell surface interactions pathway
REACT_199052
Degradation of the extracellular matrix pathway
REACT_199055
Collagen degradation pathway
KEGG
mmu04974
Protein digestion and absorption pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13552
Integrin cell surface interactions pathway
REACT_150180
Assembly of collagen fibrils and other multimeric structures pathway
REACT_121139
Collagen biosynthesis and modifying enzymes pathway
REACT_118682
Activation of Matrix Metalloproteinases pathway
REACT_150401
Collagen degradation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_169262
Laminin interactions pathway
REACT_120729
Collagen formation pathway
KEGG
hsa04974
Protein digestion and absorption pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
p53downstreampathway
Direct p53 effectors
hnf3apathway
FOXA1 transcription factor network
Cross-References
SwissProt P39061
TrEMBL D3Z556
UniProt Splice Variant
Entrez Gene 12822
UniGene Mm.4352
RefSeq NM_009929 XM_006513176 NM_001109991 XM_006513173 XM_006513174
OMIM
CCDS CCDS23953 CCDS48604
HPRD
IMGT
MGI ID MGI:88451
MGI Symbol Col18a1
EMBL AC055777 AC159334 AF257775 AK014292 AK031798 BC064817 BC066080 D17546 L16898 L22545 U03714 U03715 U03716 U03718 U11636 U11637 U34606 U34607 U34608 U34609 U34610 U34611 U34612 U34613
GenPept AAA19787 AAA20657 AAA37434 AAC52178 AAC52179 AAC52901 AAC52902 AAC52903 AAF69009 AAH64817 AAH66080 BAA04483 BAB29249 BAC27554
RNA Seq Atlas 12822

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca