Homo sapiens Gene: TLE2
Summary
InnateDB Gene IDBG-16680.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TLE2
Gene Name transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
Synonyms ESG; ESG2; GRG2;
Species Homo sapiens
Ensembl Gene ENSG00000065717
Encoded Proteins
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:2997638-3047635
Strand Reverse strand
Band p13.3
Transcripts
ENST00000262953 ENSP00000262953
ENST00000443826 ENSP00000392427
ENST00000455444 ENSP00000413107
ENST00000426948 ENSP00000392869
ENST00000586422 ENSP00000465519
ENST00000586492
ENST00000587770
ENST00000591457 ENSP00000467337
ENST00000591720
ENST00000590183
ENST00000587672
ENST00000589205
ENST00000591529 ENSP00000468279
ENST00000587893
ENST00000589291
ENST00000592305
ENST00000587137 ENSP00000467358
ENST00000587217
ENST00000590101
ENST00000590536 ENSP00000466542
ENST00000589364 ENSP00000465292
ENST00000592584 ENSP00000468666
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0007219 Notch signaling pathway
GO:0009887 organ morphogenesis
GO:0016055 Wnt signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
truncated APC mutants destabilize the destruction complex pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
AMER1 mutants destabilize the destruction complex pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
AXIN missense mutants destabilize the destruction complex pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Signaling by Wnt pathway
Signaling by NOTCH1 in Cancer pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of beta-catenin by the destruction complex pathway
deactivation of the beta-catenin transactivating complex pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signal Transduction pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
repression of WNT target genes pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
formation of the beta-catenin:TCF transactivating complex pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
KEGG
INOH
TGF-beta signaling pathway
Wnt signaling pathway pathway
PID BIOCARTA
PID NCI
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 7089
UniGene Hs.332173
RefSeq NM_001144761 NM_001144762 NM_001300846 NM_003260 XM_005259636 XM_006722864
HUGO HGNC:11838
OMIM 601041
CCDS CCDS45911 CCDS45912 CCDS45913 CCDS74255
HPRD 03025
IMGT
EMBL
GenPept
RNA Seq Atlas 7089