Homo sapiens Gene: GRB10
Summary
InnateDB Gene IDBG-16688.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRB10
Gene Name growth factor receptor-bound protein 10
Synonyms Grb-10; GRB-IR; IRBP; MEG1; RSS;
Species Homo sapiens
Ensembl Gene ENSG00000106070
Encoded Proteins
growth factor receptor-bound protein 10
growth factor receptor-bound protein 10
growth factor receptor-bound protein 10
growth factor receptor-bound protein 10
growth factor receptor-bound protein 10
growth factor receptor-bound protein 10
growth factor receptor-bound protein 10
growth factor receptor-bound protein 10
growth factor receptor-bound protein 10
growth factor receptor-bound protein 10
growth factor receptor-bound protein 10
growth factor receptor-bound protein 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:50590063-50793462
Strand Reverse strand
Band p12.1
Transcripts
ENST00000335866 ENSP00000338543
ENST00000357271 ENSP00000349818
ENST00000398812 ENSP00000381793
ENST00000398810 ENSP00000381790
ENST00000401949 ENSP00000385770
ENST00000403097 ENSP00000385544
ENST00000402578 ENSP00000385189
ENST00000406641 ENSP00000385366
ENST00000407526 ENSP00000385046
ENST00000402497 ENSP00000385748
ENST00000428711 ENSP00000410920
ENST00000439044 ENSP00000413023
ENST00000461886
ENST00000473696
ENST00000482397
ENST00000465602
ENST00000483819
ENST00000470992
ENST00000483157
ENST00000492265
ENST00000467386
ENST00000478162
ENST00000490051
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 55 [view]
Protein-Protein 55 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005158 insulin receptor binding
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0008286 insulin receptor signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032868 response to insulin
GO:0042326 negative regulation of phosphorylation
GO:0042327 positive regulation of phosphorylation
GO:0045719 negative regulation of glycogen biosynthetic process
GO:0046325 negative regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0048009 insulin-like growth factor receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
KitReceptor pathway
REACTOME
SHC-related events pathway
SHC activation pathway
Signaling by SCF-KIT pathway
Signal Transduction pathway
Insulin receptor signalling cascade pathway
IRS-related events pathway
IRS activation pathway
Signal attenuation pathway
Signaling by Insulin receptor pathway
KEGG
INOH
PID BIOCARTA
PID NCI
IGF1 pathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Signaling events mediated by VEGFR1 and VEGFR2
Signaling events regulated by Ret tyrosine kinase
PDGFR-beta signaling pathway
Insulin Pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.164060 Hs.626978 Hs.737720
RefSeq NM_001001549 NM_001001550 NM_001001555 NM_005311 XM_005271760 XM_005271761 XM_005271765 XM_005271766 XM_005271767 XM_006715703 XM_006715704 XM_006715705
HUGO
OMIM
CCDS CCDS43582 CCDS43583 CCDS47586
HPRD 03312
IMGT
EMBL
GenPept
RNA Seq Atlas