Version 5.4
Mus musculus Gene: Ruvbl1
Summary
InnateDB Gene IDBG-166976.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ruvbl1
Gene Name RuvB-like protein 1
Synonyms 2510009G06Rik; Pontin52; Tip49a
Species Mus musculus
Ensembl Gene ENSMUSG00000030079
Encoded Proteins
IDBP-166978
RuvB-like protein 1
IDBP-533788
RuvB-like protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175792:
Gene Information
Type Protein coding
Genomic Location Chromosome 6:88465409-88497572
Strand Forward strand
Band D1
Transcripts
ENSMUST00000032165 ENSMUSP00000032165
ENSMUST00000129035 ENSMUSP00000117925
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 173 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 173 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003678 DNA helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0009378 four-way junction helicase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0043141 ATP-dependent 5'-3' DNA helicase activity
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007067 mitotic nuclear division
GO:0032508 DNA duplex unwinding
GO:0040008 regulation of growth
GO:0043967 histone H4 acetylation
GO:0043968 histone H2A acetylation
Cellular Component
GO:0000812 Swr1 complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0030529 ribonucleoprotein complex
GO:0031011 Ino80 complex
GO:0035267 NuA4 histone acetyltransferase complex
GO:0043231 intracellular membrane-bounded organelle
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
GO:0071339 MLL1 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000175792
View Gene Order
ENSBTAG00000020998
Not yet available
Pathways
NETPATH
REACTOME
REACT_218274
Chromatin organization pathway
REACT_189085
Disease pathway
REACT_233453
Chromosome Maintenance pathway
REACT_214014
Signaling by Wnt pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_226917
HATs acetylate histones pathway
REACT_188804
Cell Cycle pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_216539
formation of the beta-catenin:TCF transactivating complex pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_198595
Nucleosome assembly pathway
REACT_198597
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_188257
Signal Transduction pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
mmu04310
Wnt signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22186
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_7974
Telomere Extension By Telomerase pathway
REACT_172610
HATs acetylate histones pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_22172
Chromosome Maintenance pathway
REACT_22344
Nucleosome assembly pathway
REACT_7970
Telomere Maintenance pathway
REACT_111102
Signal Transduction pathway
REACT_115566
Cell Cycle pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_200753
formation of the beta-catenin:TCF transactivating complex pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_8030
Extension of Telomeres pathway
REACT_116125
Disease pathway
KEGG
hsa04310
Wnt signaling pathway pathway
INOH
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
ilk_pathway
Integrin-linked kinase signaling
myc_pathway
C-MYC pathway
Cross-References
SwissProt P60122
TrEMBL D3YW60 Q3U1C2
UniProt Splice Variant
Entrez Gene 56505
UniGene Mm.42195
RefSeq NM_019685
OMIM
CCDS CCDS20336
HPRD
IMGT
MGI ID MGI:1928760
MGI Symbol Ruvbl1
EMBL AC153694 AC154038 AF100694 AK132783 AK156078 BC004718 CH466523
GenPept AAD02877 AAH04718 BAE21358 BAE33576 EDK99249
RNA Seq Atlas 56505

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca