Version 5.4
Mus musculus Gene: Pttg1ip
Summary
InnateDB Gene IDBG-167332.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pttg1ip
Gene Name pituitary tumor-transforming 1 interacting protein
Synonyms 1810010L20Rik; AI314311; AU018448; C79540
Species Mus musculus
Ensembl Gene ENSMUSG00000009291
Encoded Proteins
IDBP-167334
pituitary tumor-transforming 1 interacting protein
IDBP-534370
pituitary tumor-transforming 1 interacting protein
IDBP-542127
pituitary tumor-transforming 1 interacting protein
IDBP-540366
pituitary tumor-transforming 1 interacting protein
IDBP-534649
pituitary tumor-transforming 1 interacting protein
IDBP-539160
pituitary tumor-transforming 1 interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183255:
The encoded protein, which directly binds to pituitary tumor-transforming gene 1 protein (PTTG1), facilitates the nuclear translocation of PTTG1 and potentiates the transcriptional activation of basic fibroblast growth factor by PTTG1. The gene product localizes to both the cytoplasm and nucleus. Its NLS is required for its own nuclear localization, the nuclear localization of PTTG1, and its interaction with PTTG1. [provided by RefSeq, Jul 2008]
This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic fibroblast growth factor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:77581720-77598732
Strand Forward strand
Band C1
Transcripts
ENSMUST00000009435 ENSMUSP00000009435
ENSMUST00000159116
ENSMUST00000161789 ENSMUSP00000125094
ENSMUST00000162429 ENSMUSP00000124457
ENSMUST00000162598 ENSMUSP00000124652
ENSMUST00000162943 ENSMUSP00000124313
ENSMUST00000161165 ENSMUSP00000124774
ENSMUST00000162895
ENSMUST00000167006
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004872 receptor activity
Biological Process
GO:0006606 protein import into nucleus
GO:0007275 multicellular organismal development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000183255
View Gene Order
ENSBTAG00000021771
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.28853 Mm.415462
RefSeq NM_145925
OMIM
CCDS CCDS23957
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca