Version 5.4
Mus musculus Gene: Snapin
Summary
InnateDB Gene IDBG-167545.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Snapin
Gene Name SNAP-associated protein
Synonyms 25kDa; AA407989; AV026596; Bloc1s7; Snap25bp; Snapap
Species Mus musculus
Ensembl Gene ENSMUSG00000001018
Encoded Proteins
IDBP-536568
SNAP-associated protein
IDBP-788517
SNAP-associated protein
IDBP-788518
SNAP-associated protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143553:
The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:90488026-90491033
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000107352
ENSMUST00000107351
ENSMUST00000149884 ENSMUSP00000122090
ENSMUST00000185005 ENSMUSP00000139160
ENSMUST00000184877 ENSMUSP00000139315
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 65 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000149 SNARE binding
GO:0005515 protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0007268 synaptic transmission
GO:0008089 anterograde axon cargo transport
GO:0010977 negative regulation of neuron projection development
GO:0016079 synaptic vesicle exocytosis
GO:0016188 synaptic vesicle maturation
GO:0017156 calcium ion-dependent exocytosis
GO:0031175 neuron projection development
GO:0031629 synaptic vesicle fusion to presynaptic membrane
GO:0043393 regulation of protein binding
GO:0048489 synaptic vesicle transport
GO:0048490 anterograde synaptic vesicle transport
GO:0072553 terminal button organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005730 nucleolus
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0008021 synaptic vesicle
GO:0030054 cell junction
GO:0030133 transport vesicle
GO:0030141 secretory granule
GO:0030672 synaptic vesicle membrane
GO:0031083 BLOC-1 complex
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000143553
View Gene Order
ENSBTAG00000012470
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_232671
Golgi Associated Vesicle Biogenesis pathway
REACT_243409
trans-Golgi Network Vesicle Budding pathway
REACT_234979
Clathrin derived vesicle budding pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_133854
OMIM
CCDS CCDS17531
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca