Version 5.4
Mus musculus Gene: S100a6
Summary
InnateDB Gene IDBG-168016.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol S100a6
Gene Name S100 calcium binding protein A6 (calcyclin)
Synonyms 2A9; 5B10; Cacy; CALCYCLIN; PRA
Species Mus musculus
Ensembl Gene ENSMUSG00000001025
Encoded Proteins
IDBP-168018
S100 calcium binding protein A6 (calcyclin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197956:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:90612894-90614414
Strand Forward strand
Band F1
Transcripts
ENSMUST00000001051 ENSMUSP00000001051
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005523 tropomyosin binding
GO:0008270 zinc ion binding
GO:0015075 ion transmembrane transporter activity
GO:0042803 protein homodimerization activity
GO:0044548 S100 protein binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0034220 ion transmembrane transport
Cellular Component
GO:0001726 ruffle
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000197956
View Gene Order
Cross-References
SwissProt P14069
TrEMBL Q545I9
UniProt Splice Variant
Entrez Gene 20200
UniGene
RefSeq NM_011313
OMIM
CCDS CCDS38506
HPRD
IMGT
MGI ID MGI:1339467
MGI Symbol S100a6
EMBL AF549497 AK008241 AK008941 AK150408 AK151144 AK151587 BC003832 BC010774 CH466547 M37761 X52278 X66449
GenPept AAA37358 AAH03832 AAH10774 AAN59899 BAB25552 BAB25982 BAE29534 BAE30151 BAE30527 CAA36521 CAA47065 EDL15114
RNA Seq Atlas 20200

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca