Version 5.4
| Mus musculus Gene: Ndufa7 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-168019.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | Ndufa7 | ||||||||||||||||||
| Gene Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a) | ||||||||||||||||||
| Synonyms | 14.5kDa; 2400007M02Rik; CI-B14.5a | ||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||
| Ensembl Gene | ENSMUSG00000041881 | ||||||||||||||||||
| Encoded Proteins |
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a)
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a)
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. Complex I has been biochemically separated into four fractions. The bovine ortholog of this protein has been reported to be part of the I-lambda fraction, which forms the extrinsic globular domain. In humans, deficiencies in complex I are associated with myopathies, encephalomyopathies, and neurodegenerative disorders. Pseudogenes of this gene are located on chromosomes 7 and 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 17:33824591-33838316 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | B1 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
The citric acid (TCA) cycle and respiratory electron transport pathway
Respiratory electron transport pathway
Metabolism pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
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| KEGG |
Oxidative phosphorylation pathway
Alzheimer's disease pathway
Parkinson's disease pathway
Huntington's disease pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
The citric acid (TCA) cycle and respiratory electron transport pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Metabolism pathway
Respiratory electron transport pathway
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| KEGG |
Alzheimer's disease pathway
Oxidative phosphorylation pathway
Parkinson's disease pathway
Huntington's disease pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q9Z1P6 | ||||||||||||||||||
| TrEMBL | G3UXZ4 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 66416 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_023202 | ||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS28631 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| MGI ID | MGI:1913666 | ||||||||||||||||||
| MGI Symbol | Ndufa7 | ||||||||||||||||||
| EMBL | AF110520 AF528162 AK002476 AK003468 AK010299 BC052817 BC055698 CT030732 | ||||||||||||||||||
| GenPept | AAC97968 AAH52817 AAH55698 AAO17379 BAB22129 BAB22805 BAB26832 | ||||||||||||||||||
| RNA Seq Atlas | 66416 | ||||||||||||||||||