Mus musculus Gene: S100a9 | |||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-168119.6 | ||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||
Gene Symbol | S100a9 | ||||||||||||||||||||||||||||||
Gene Name | S100 calcium binding protein A9 (calgranulin B) | ||||||||||||||||||||||||||||||
Synonyms | 60B8Ag; AW546964; BEE22; Cagb; GAGB; L1Ag; MRP14; p14 | ||||||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000056071 | ||||||||||||||||||||||||||||||
Encoded Proteins |
S100 calcium binding protein A9 (calgranulin B)
S100 calcium binding protein A9 (calgranulin B)
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Protein Structure | |||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||||
Summary |
S100a9 forms a complex with S100a8 and the complex is the site of interplay between extracellular Ca(2+) entry and intra-phagosomal reactive oxygen species production. S100a8 :: S100a9 acts as Ca(2+) sensor in phagosomal ROS production.
S100a9-deficient murine neutrophils exhibited a reduce secretion of cytokines in response to Tlr4 stimulation. In contrast, S100a9-deficient dendritic cells showed an exacerbated release of cytokines after TLR stimulation. S100a9 has no effect on the inflammatory status of macrophages.
S100a9 is strongly upregulated in neutrophils upon bacterial infection, and sequesters zinc as a mechanism of nutritional immunity. Salmonella typhimurium overcomes this defence mechanism by expressing a high affinity zinc transporter.
S100A9 forms a heterodimer with S100A8 and is a key player in protective innate immunity during Klebsiella pneumonia infection.
S100a8/S100a9 are proinflammatory proteins that activate natural killer cells via Ager signalling.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||
Summary |
[Homo sapiens] S100A9 is an intracellular calcium-binding protein that promotes neutrophil/monocyte recruitment at inflamed tissues by enhancing attachment to endothelial cells.
[Homo sapiens] S100A9 is a myeloid-related protein that rapidly modulates macrophage nitric oxide production during innate immune response.
[Homo sapiens] S100A9 (calgranulin B) and S100A8 (calgranulin A) form an antimicrobial heterodimeric complex known as calprotectin. Bacterial flagellin induces the upregulation of S100A9/S100A8 heterodimer via a TLR5-dependent mechanism in epidermal keratinocytes.
[Homo sapiens] S100A9 forms a complex with S100A8 and the complex is the site of interplay between extracellular Ca(2+) entry and intra-phagosomal reactive oxygen species production. S100A8 :: S100A9 acts as Ca(2+) sensor in phagosomal ROS production.
[Homo sapiens] S100A9-deficient murine neutrophils exhibited a reduce secretion of cytokines in response to TLR4 stimulation. In contrast, S100A9-deficient dendritic cells showed an exacerbated release of cytokines after TLR stimulation. S100A9 has no effect on the inflammatory status of macrophages. (Demonstrated in murine model)
[Homo sapiens] S100A9 is strongly upregulated in neutrophils upon bacterial infection, and sequesters zinc as a mechanism of nutritional immunity. Salmonella typhimurium overcomes this defence mechanism by expressing a high affinity zinc transporter. (Demonstrated in mice)
[Homo sapiens] S100A9 forms a heterodimer with S100A8 and is a key player in protective innate immunity during Klebsiella pneumonia infection.
[Homo sapiens] S100A8::S100A9 heterodimer sequesters Mn(2+) and Zn(2+) to starve bacteria of these essential nutrients.
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Entrez Gene | |||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163220:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||
Genomic Location | Chromosome 3:90692632-90695721 | ||||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||||
Band | F1 | ||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||||||||||
KEGG | |||||||||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||||||||
PID NCI |
Endogenous TLR signaling
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Cross-References | |||||||||||||||||||||||||||||||
SwissProt | P31725 | ||||||||||||||||||||||||||||||
TrEMBL | Q3UP42 | ||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||
Entrez Gene | 20202 | ||||||||||||||||||||||||||||||
UniGene | Mm.2128 | ||||||||||||||||||||||||||||||
RefSeq | NM_001281852 NM_009114 | ||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||
CCDS | CCDS17543 | ||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||
MGI ID | MGI:1338947 | ||||||||||||||||||||||||||||||
MGI Symbol | S100a9 | ||||||||||||||||||||||||||||||
EMBL | AJ250496 AK143826 BC027635 CH466547 M83219 | ||||||||||||||||||||||||||||||
GenPept | AAB07228 AAH27635 BAE25555 CAC14292 EDL15109 EDL15110 | ||||||||||||||||||||||||||||||
RNA Seq Atlas | 20202 | ||||||||||||||||||||||||||||||