Mus musculus Gene: Polr2i
Summary
InnateDB Gene IDBG-168174.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Polr2i
Gene Name polymerase (RNA) II (DNA directed) polypeptide I
Synonyms 2810002B19Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000019738
Encoded Proteins
polymerase (RNA) II (DNA directed) polypeptide I
polymerase (RNA) II (DNA directed) polypeptide I
polymerase (RNA) II (DNA directed) polypeptide I
polymerase (RNA) II (DNA directed) polypeptide I
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105258:
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:30231948-30233390
Strand Forward strand
Band B1
Transcripts
ENSMUST00000019882 ENSMUSP00000019882
ENSMUST00000108193 ENSMUSP00000103828
ENSMUST00000108192 ENSMUSP00000103827
ENSMUST00000149654 ENSMUSP00000116741
ENSMUST00000145559
ENSMUST00000138118
ENSMUST00000150841
ENSMUST00000138886
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity
GO:0008270 zinc ion binding
Biological Process
GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006351 transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005665 DNA-directed RNA polymerase II, core complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
Transcription-coupled NER (TC-NER) pathway
Formation of the Early Elongation Complex pathway
mRNA Splicing pathway
Formation of transcription-coupled NER (TC-NER) repair complex pathway
RNA Polymerase II Transcription Initiation pathway
mRNA Splicing - Minor Pathway pathway
RNA Polymerase II Promoter Escape pathway
Nucleotide Excision Repair pathway
Formation of RNA Pol II elongation complex pathway
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
DNA Repair pathway
Transcriptional regulation by small RNAs pathway
RNA Polymerase II Transcription Elongation pathway
RNA Polymerase II Pre-transcription Events pathway
mRNA Capping pathway
Gene Expression pathway
Regulatory RNA pathways pathway
mRNA Splicing - Major Pathway pathway
Dual incision reaction in TC-NER pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
RNA Polymerase II Transcription pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
KEGG
Pyrimidine metabolism pathway
RNA polymerase pathway
Purine metabolism pathway
Huntington's disease pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Tat-mediated HIV elongation arrest and recovery pathway
Pausing and recovery of Tat-mediated HIV elongation pathway
Viral Messenger RNA Synthesis pathway
mRNA Splicing - Major Pathway pathway
mRNA Splicing - Minor Pathway pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Capping pathway
MicroRNA (miRNA) biogenesis pathway
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
RNA Polymerase II Pre-transcription Events pathway
Formation of RNA Pol II elongation complex pathway
Formation of the Early Elongation Complex pathway
RNA Polymerase II Transcription Elongation pathway
RNA Polymerase II Promoter Escape pathway
RNA Polymerase II Transcription Initiation pathway
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
Formation of HIV elongation complex in the absence of HIV Tat pathway
HIV Transcription Initiation pathway
Pausing and recovery of HIV elongation pathway
RNA Polymerase II HIV Promoter Escape pathway
Formation of the HIV-1 Early Elongation Complex pathway
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
Tat-mediated elongation of the HIV-1 transcript pathway
Abortive elongation of HIV-1 transcript in the absence of Tat pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
HIV elongation arrest and recovery pathway
Transcription of the HIV genome pathway
Late Phase of HIV Life Cycle pathway
Formation of transcription-coupled NER (TC-NER) repair complex pathway
Dual incision reaction in TC-NER pathway
Transcription-coupled NER (TC-NER) pathway
Influenza Infection pathway
Transcriptional regulation by small RNAs pathway
Influenza Viral RNA Transcription and Replication pathway
HIV Transcription Elongation pathway
RNA Polymerase II Transcription pathway
HIV Life Cycle pathway
HIV Infection pathway
Influenza Life Cycle pathway
mRNA Splicing pathway
Nucleotide Excision Repair pathway
Gene Expression pathway
Disease pathway
DNA Repair pathway
Regulatory RNA pathways pathway
KEGG
Pyrimidine metabolism pathway
Purine metabolism pathway
RNA polymerase pathway
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_027259
OMIM
CCDS CCDS21084
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas