Version 5.4
Homo sapiens Gene: ERLIN2
Summary
InnateDB Gene IDBG-16836.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERLIN2
Gene Name ER lipid raft associated 2
Synonyms C8orf2; Erlin-2; NET32; SPFH2; SPG18
Species Homo sapiens
Ensembl Gene ENSG00000147475
Encoded Proteins
IDBP-16838
ER lipid raft associated 2
IDBP-16840
ER lipid raft associated 2
IDBP-235817
ER lipid raft associated 2
IDBP-479652
ER lipid raft associated 2
IDBP-477663
ER lipid raft associated 2
IDBP-477425
ER lipid raft associated 2
IDBP-483026
ER lipid raft associated 2
IDBP-812958
ER lipid raft associated 2
IDBP-481854
ER lipid raft associated 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:37736599-37759101
Strand Forward strand
Band p11.23
Transcripts
ENST00000335171 ENSP00000335220
ENST00000276461 ENSP00000276461
ENST00000397228 ENSP00000380405
ENST00000519872
ENST00000518526 ENSP00000429229
ENST00000523887 ENSP00000429903
ENST00000518586 ENSP00000427847
ENST00000521644 ENSP00000429621
ENST00000523107 ENSP00000473292
ENST00000519638 ENSP00000428112
ENST00000521993
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 49 [view]
Protein-Protein 49 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008219 cell death
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031483
View Gene Order
ENSBTAG00000017831
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.603403 Hs.606684 Hs.624471 Hs.669261 Hs.705490
RefSeq NM_001003790 NM_001003791 NM_007175 XM_005273391 XM_005273393
HUGO
OMIM
CCDS CCDS34879 CCDS6095
HPRD 15437
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca