InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hmox1

Summary

InnateDB Gene

IDBG-168890.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hmox1

Gene Name

heme oxygenase (decycling) 1

Synonyms

D8Wsu38e; Hemox; Hmox; HO-1; HO1; Hsp32

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005413

Encoded Proteins

IDBP-168894

heme oxygenase (decycling) 1

IDBP-717700

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21307647

Hmox1, a downstream signalling molecule in the Tlr4 pathway, is necessary for LPS-induced autophagy signalling in macrophages.

InnateDB Annotation from Orthologs

Summary

PMID 21307647

[Homo sapiens] HMOX1, a downstream signalling molecule in the TLR4 pathway, is necessary for LPS-induced autophagy signalling in macrophages.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100292:
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:75093591-75100596

Strand

Forward strand

Band

Transcripts

ENSMUST00000005548	ENSMUSP00000005548
ENSMUST00000160341
ENSMUST00000159631	ENSMUSP00000135466

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	5 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004392	heme oxygenase (decyclizing) activity
GO:0004630	phospholipase D activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0001666	response to hypoxia
GO:0002246	wound healing involved in inflammatory response
GO:0006788	heme oxidation
GO:0006979	response to oxidative stress
GO:0007264	small GTPase mediated signal transduction
GO:0008217	regulation of blood pressure
GO:0008219	cell death
GO:0008285	negative regulation of cell proliferation
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010656	negative regulation of muscle cell apoptotic process
GO:0031670	cellular response to nutrient
GO:0032764	negative regulation of mast cell cytokine production
GO:0034101	erythrocyte homeostasis
GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron
GO:0035094	response to nicotine
GO:0035556	intracellular signal transduction
GO:0042167	heme catabolic process
GO:0042168	heme metabolic process
GO:0042542	response to hydrogen peroxide
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043305	negative regulation of mast cell degranulation
GO:0043392	negative regulation of DNA binding
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043524	negative regulation of neuron apoptotic process
GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043627	response to estrogen
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
GO:0051260	protein homooligomerization
GO:0055072	iron ion homeostasis
GO:0055114	oxidation-reduction process
GO:0071243	cellular response to arsenic-containing substance
GO:0071276	cellular response to cadmium ion
GO:0071456	cellular response to hypoxia
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors