Version 5.4
Mus musculus Gene: Mcm5
Summary
InnateDB Gene IDBG-168946.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mcm5
Gene Name minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
Synonyms AA617332; AI324988; AL033333; Cdc46; mCD46; mCDC46; Mcmd5; P1-CDC46
Species Mus musculus
Ensembl Gene ENSMUSG00000005410
Encoded Proteins
IDBP-620767
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100297:
The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:75109528-75128439
Strand Forward strand
Band C1
Transcripts
ENSMUST00000164309 ENSMUSP00000126135
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0032508 DNA duplex unwinding
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
GO:0042555 MCM complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100297
View Gene Order
ENSBTAG00000015595
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03030
DNA replication pathway
mmu04110
Cell cycle pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_1156
Orc1 removal from chromatin pathway
REACT_207
Removal of licensing factors from origins pathway
REACT_2148
Switching of origins to a post-replicative state pathway
REACT_6776
Unwinding of DNA pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_2243
Assembly of the pre-replicative complex pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_828
G2/M Checkpoints pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_932
DNA strand elongation pathway
REACT_829
Regulation of DNA replication pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
hsa03030
DNA replication pathway
hsa04110
Cell cycle pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q52KC3
UniProt Splice Variant
Entrez Gene 17218
UniGene Mm.5048
RefSeq NM_008566 XM_006530750
OMIM
CCDS CCDS22424
HPRD
IMGT
MGI ID MGI:103197
MGI Symbol Mcm5
EMBL AC084823 AK133826 BC094416 CH466525
GenPept AAH94416 BAE21865 EDL10827 EDL10828 EDL10829
RNA Seq Atlas 17218

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca