InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Aldh1l1

Summary

InnateDB Gene

IDBG-168985.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aldh1l1

Gene Name

aldehyde dehydrogenase 1 family, member L1

Synonyms

1810048F20Rik; FDH; Fthfd; Neut2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030088

Encoded Proteins

IDBP-168987

aldehyde dehydrogenase 1 family, member L1

IDBP-538393

aldehyde dehydrogenase 1 family, member L1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144908:
The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:90486427-90600203

Strand

Forward strand

Band

Transcripts

ENSMUST00000032175	ENSMUSP00000032175
ENSMUST00000127199
ENSMUST00000130418	ENSMUSP00000114304
ENSMUST00000152436
ENSMUST00000137669

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0016155	formyltetrahydrofolate dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0016742	hydroxymethyl-, formyl- and related transferase activity

Biological Process

GO:0006730	one-carbon metabolic process
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0009258	10-formyltetrahydrofolate catabolic process
GO:0032259	methylation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000144908

View Gene Order

ENSBTAG00000014470

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00670

One carbon pool by folate pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00670

One carbon pool by folate pathway

INOH

INOH website

Folate metabolism pathway

PID NCI

Cross-References

SwissProt

Q8R0Y6

TrEMBL

Q8BLE0 Q9CVJ8

UniProt Splice Variant

Entrez Gene

107747

UniGene

Mm.30035

RefSeq

NM_027406 XM_006505279

OMIM

CCDS

CCDS20361

HPRD

IMGT

MGI ID

MGI:1340024

MGI Symbol

Aldh1l1

EMBL

AK007822 AK045441 BC025939 BC028817 BC030722 BC030723 BC030727 BC030730

GenPept

AAH25939 AAH28817 AAH30722 AAH30723 AAH30727 AAH30730 BAB25285 BAC32369

RNA Seq Atlas

107747