InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ring1

Summary

InnateDB Gene

IDBG-169288.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ring1

Gene Name

ring finger protein 1

Synonyms

Ring1A

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024325

Encoded Proteins

IDBP-169290

ring finger protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204227:
This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:34020792-34024680

Strand

Reverse strand

Band

Transcripts

ENSMUST00000025183	ENSMUSP00000025183
ENSMUST00000174054
ENSMUST00000172739

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0009952	anterior/posterior pattern specification
GO:0016574	histone ubiquitination
GO:0035518	histone H2A monoubiquitination
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048593	camera-type eye morphogenesis

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0001739	sex chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016604	nuclear body
GO:0016607	nuclear speck
GO:0031519	PcG protein complex
GO:0035102	PRC1 complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000204227

View Gene Order

ENSBTAG00000018884

Not yet available

Pathways

NETPATH

REACTOME

REACT_188970

Oxidative Stress Induced Senescence pathway

REACT_188957

Cellular responses to stress pathway

REACT_188820

Cellular Senescence pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_3

Notch pathway

REACTOME

REACT_120956

Cellular responses to stress pathway

REACT_169274

Cellular Senescence pathway

REACT_169436

Oxidative Stress Induced Senescence pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.20343 Mm.484326

RefSeq

NM_009066

OMIM

CCDS

CCDS50070

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas