Homo sapiens Gene: EGFR
Summary
InnateDB Gene IDBG-16933.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EGFR
Gene Name epidermal growth factor receptor
Synonyms ERBB; ERBB1; HER1; mENA; PIG61;
Species Homo sapiens
Ensembl Gene ENSG00000146648
Encoded Proteins
epidermal growth factor receptor
epidermal growth factor receptor
epidermal growth factor receptor
epidermal growth factor receptor
epidermal growth factor receptor
epidermal growth factor receptor
epidermal growth factor receptor
epidermal growth factor receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
EGFR is the receptor for epidermal growth factor (EGF) and signalling through growth factor receptors controls diverse cell functions such as proliferation, migration, and differentiation.
EGFR-induced cell migration is mediated predominantly by the JAK-STAT pathway in primary esophageal keratinocytes.
EGFR and TLR4 are activated by neutrophil elastase (ELA2) to produce IL8 through a novel metalloprotease pathway.
Human papillomaviruses impair the acetylation of NFκB/RelA K310 in keratinocytes by augmenting the expression of interferon-related developmental regulator 1 (IFRD1) in an EGFR-dependent manner.
Human papillomaviruses impair the acetylation of NFκB/RelA K310 in keratinocytes by augmenting the expression of interferon-related developmental regulator 1 (IFRD1) in an EGFR-dependent manner.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Il33-dependent group 2 innate lymphoid cells (ILC2s) signal via Areg-Egfr in damaged epithelia to restore epithelial barrier function and maintain tissue homeostasis.
Entrez Gene
Summary The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:55019021-55256620
Strand Forward strand
Band p11.2
Transcripts
ENST00000275493 ENSP00000275493
ENST00000344576 ENSP00000345973
ENST00000342916 ENSP00000342376
ENST00000455089 ENSP00000415559
ENST00000420316 ENSP00000413843
ENST00000454757 ENSP00000395243
ENST00000442591 ENSP00000410031
ENST00000450046 ENSP00000413354
ENST00000459688
ENST00000463948
ENST00000485503
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 800 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 800 [view]
Protein-Protein 790 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004672 protein kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 receptor signaling protein tyrosine kinase activity
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005102 receptor binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030235 nitric-oxide synthase regulator activity
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0000902 cell morphogenesis
GO:0001503 ossification
GO:0001889 liver development
GO:0001892 embryonic placenta development
GO:0001934 positive regulation of protein phosphorylation
GO:0001942 hair follicle development
GO:0006412 translation
GO:0006468 protein phosphorylation
GO:0006950 response to stress
GO:0006970 response to osmotic stress
GO:0006979 response to oxidative stress
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007411 axon guidance
GO:0007435 salivary gland morphogenesis
GO:0007611 learning or memory
GO:0007623 circadian rhythm
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008544 epidermis development
GO:0010960 magnesium ion homeostasis
GO:0014070 response to organic cyclic compound
GO:0016101 diterpenoid metabolic process
GO:0016337 single organismal cell-cell adhesion
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019694 alkanesulfonate metabolic process
GO:0021795 cerebral cortex cell migration
GO:0023014 signal transduction by phosphorylation
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0031659 positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0032355 response to estradiol
GO:0032930 positive regulation of superoxide anion generation
GO:0033590 response to cobalamin
GO:0033594 response to hydroxyisoflavone
GO:0033993 response to lipid
GO:0035413 positive regulation of catenin import into nucleus
GO:0035556 intracellular signal transduction
GO:0035690 cellular response to drug
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042127 regulation of cell proliferation
GO:0042177 negative regulation of protein catabolic process
GO:0042327 positive regulation of phosphorylation
GO:0042698 ovulation cycle
GO:0042743 hydrogen peroxide metabolic process
GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling
GO:0043066 negative regulation of apoptotic process
GO:0043406 positive regulation of MAP kinase activity
GO:0043586 tongue development
GO:0045087 innate immune response (InnateDB)
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045739 positive regulation of DNA repair
GO:0045740 positive regulation of DNA replication
GO:0045907 positive regulation of vasoconstriction
GO:0045909 positive regulation of vasodilation
GO:0045930 negative regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046777 protein autophosphorylation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048143 astrocyte activation
GO:0048146 positive regulation of fibroblast proliferation
GO:0048546 digestive tract morphogenesis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048812 neuron projection morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050729 positive regulation of inflammatory response
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051205 protein insertion into membrane
GO:0051592 response to calcium ion
GO:0051897 positive regulation of protein kinase B signaling
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060571 morphogenesis of an epithelial fold
GO:0070141 response to UV-A
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071230 cellular response to amino acid stimulus
GO:0071260 cellular response to mechanical stimulus
GO:0071363 cellular response to growth factor stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0071549 cellular response to dexamethasone stimulus
Cellular Component
GO:0000139 Golgi membrane
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0030122 AP-2 adaptor complex
GO:0030139 endocytic vesicle
GO:0031965 nuclear membrane
GO:0043235 receptor complex
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
GO:0070435 Shc-EGFR complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
Alpha6Beta4Integrin pathway
AndrogenReceptor pathway
EGFR1 pathway
TNFalpha pathway
RANKL pathway
Leptin pathway
FSH pathway
Prolactin pathway
REACTOME
Signaling by FGFR in disease pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
GRB2 events in ERBB2 signaling pathway
Signaling by constitutively active EGFR pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
SHC1 events in EGFR signaling pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
GRB2 events in EGFR signaling pathway
NGF signalling via TRKA from the plasma membrane pathway
L1CAM interactions pathway
SHC1 events in ERBB2 signaling pathway
Signal transduction by L1 pathway
EGFR Transactivation by Gastrin pathway
EGFR downregulation pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
PLCG1 events in ERBB2 signaling pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
EGFR interacts with phospholipase C-gamma pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Calcium signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Endocytosis pathway
Dorso-ventral axis formation pathway
Focal adhesion pathway
Adherens junction pathway
Gap junction pathway
Regulation of actin cytoskeleton pathway
GnRH signaling pathway pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Hepatitis C pathway
Pathways in cancer pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Melanoma pathway
Bladder cancer pathway
Non-small cell lung cancer pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
EGF signaling pathway pathway
PID BIOCARTA
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Role of erbb2 in signal transduction and oncology [Biocarta view]
Map kinase inactivation of smrt corepressor [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Agrin in postsynaptic differentiation [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
Trefoil factors initiate mucosal healing [Biocarta view]
Cbl mediated ligand-induced downregulation of egf receptors pathway [Biocarta view]
Mcalpain and friends in cell motility [Biocarta view]
Sprouty regulation of tyrosine kinase signals [Biocarta view]
Egf signaling pathway [Biocarta view]
PID NCI
Thromboxane A2 receptor signaling
LPA receptor mediated events
Internalization of ErbB1
Signaling events mediated by PTP1B
Direct p53 effectors
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
ErbB1 downstream signaling
a6b1 and a6b4 Integrin signaling
Syndecan-3-mediated signaling events
EGFR-dependent Endothelin signaling events
Signaling events mediated by TCPTP
ErbB receptor signaling network
SHP2 signaling
Stabilization and expansion of the E-cadherin adherens junction
E-cadherin signaling in keratinocytes
Arf6 signaling events
Regulation of Telomerase
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.488293 Hs.605083 Hs.609934 Hs.708569 Hs.731652
RefSeq NM_005228 NM_201282 NM_201283 NM_201284
HUGO
OMIM
CCDS CCDS47587 CCDS5514 CCDS5515 CCDS5516
HPRD 00579
IMGT
EMBL
GenPept
RNA Seq Atlas