InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dab1

Summary

InnateDB Gene

IDBG-169389.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dab1

Gene Name

disabled 1

Synonyms

AI956902; C630028C02Rik; scm; scr; scrambler; yot

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028519

Encoded Proteins

disabled homolog 1 (Drosophila)

disabled homolog 1 (Drosophila)

disabled homolog 1 (Drosophila)

disabled homolog 1 (Drosophila)

disabled homolog 1 (Drosophila)

disabled homolog 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173406:
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:103619359-104744844

Strand

Forward strand

Band

C6

Transcripts

ENSMUST00000106830	ENSMUSP00000102443
ENSMUST00000106827	ENSMUSP00000102440
ENSMUST00000106826	ENSMUSP00000102439
ENSMUST00000143294
ENSMUST00000143644	ENSMUSP00000118650
ENSMUST00000146078	ENSMUSP00000125033
ENSMUST00000141037
ENSMUST00000149672	ENSMUSP00000118532

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0042169	SH2 domain binding
GO:0043548	phosphatidylinositol 3-kinase binding

Biological Process

GO:0001764	neuron migration
GO:0007162	negative regulation of cell adhesion
GO:0007264	small GTPase mediated signal transduction
GO:0007399	nervous system development
GO:0007417	central nervous system development
GO:0007420	brain development
GO:0007494	midgut development
GO:0007628	adult walking behavior
GO:0016358	dendrite development
GO:0021517	ventral spinal cord development
GO:0021589	cerebellum structural organization
GO:0021795	cerebral cortex cell migration
GO:0021799	cerebral cortex radially oriented cell migration
GO:0021813	cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration
GO:0021942	radial glia guided migration of Purkinje cell
GO:0021987	cerebral cortex development
GO:0035556	intracellular signal transduction
GO:0042493	response to drug
GO:0045666	positive regulation of neuron differentiation
GO:0045860	positive regulation of protein kinase activity
GO:0046426	negative regulation of JAK-STAT cascade
GO:0048712	negative regulation of astrocyte differentiation
GO:0050771	negative regulation of axonogenesis
GO:0051645	Golgi localization
GO:0097477	lateral motor column neuron migration

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005903	brush border
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0045177	apical part of cell
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000173406

View Gene Order

ENSBTAG00000013802

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

Reelin signaling pathway

Lissencephaly gene (LIS1) in neuronal migration and development

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.127785 Mm.289682

RefSeq

NM_177259 XM_006502731 XM_006502732

OMIM

CCDS

CCDS18413

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca