InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nr2f1

Summary

InnateDB Gene

IDBG-169423.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nr2f1

Gene Name

nuclear receptor subfamily 2, group F, member 1

Synonyms

COUP-TF1; COUP-TFI; COUPTFA; EAR3; Erbal3; SVP44; Tcfcoup1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000069171

Encoded Proteins

IDBP-169425

nuclear receptor subfamily 2, group F, member 1

IDBP-532225

nuclear receptor subfamily 2, group F, member 1

IDBP-627250

nuclear receptor subfamily 2, group F, member 1

IDBP-532438

nuclear receptor subfamily 2, group F, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175745:
The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5\'-AGGTCA-3\' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). [provided by RefSeq, Apr 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:78188973-78199757

Strand

Reverse strand

Band

Transcripts

ENSMUST00000091458	ENSMUSP00000089036
ENSMUST00000150498	ENSMUSP00000118161
ENSMUST00000127137	ENSMUSP00000133704
ENSMUST00000135284
ENSMUST00000125176	ENSMUSP00000122618

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0044323	retinoic acid-responsive element binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001764	neuron migration
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007399	nervous system development
GO:0010977	negative regulation of neuron projection development
GO:0021796	cerebral cortex regionalization
GO:0030522	intracellular receptor signaling pathway
GO:0030900	forebrain development
GO:0043401	steroid hormone mediated signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000175745

View Gene Order

ENSBTAG00000017599

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_15525

Nuclear Receptor transcription pathway pathway

REACT_12627

Generic Transcription Pathway pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.439653 Mm.472293

RefSeq

NM_010151 XM_006517085

OMIM

CCDS

CCDS26658

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas