Version 5.4
Mus musculus Gene: Rxrb
Summary
InnateDB Gene IDBG-169595.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rxrb
Gene Name retinoid X receptor beta
Synonyms AL023085; H-2RIIBP; Nr2b2; RCoR-1; Rub
Species Mus musculus
Ensembl Gene ENSMUSG00000039656
Encoded Proteins
IDBP-169597
retinoid X receptor beta
IDBP-273696
retinoid X receptor beta
IDBP-626916
retinoid X receptor beta
IDBP-626920
retinoid X receptor beta
IDBP-626921
retinoid X receptor beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204231:
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:34031812-34038393
Strand Forward strand
Band B1
Transcripts
ENSMUST00000044858 ENSMUSP00000036585
ENSMUST00000116612 ENSMUSP00000112311
ENSMUST00000174299 ENSMUSP00000133775
ENSMUST00000173554 ENSMUSP00000134299
ENSMUST00000173354 ENSMUSP00000133661
ENSMUST00000174740
ENSMUST00000174130
ENSMUST00000174645
ENSMUST00000174033
ENSMUST00000174578
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004886 9-cis retinoic acid receptor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001893 maternal placenta development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0043401 steroid hormone mediated signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048384 retinoic acid receptor signaling pathway
GO:0055012 ventricular cardiac muscle cell differentiation
GO:0060038 cardiac muscle cell proliferation
GO:0071300 cellular response to retinoic acid
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000204231
View Gene Order
ENSBTAG00000000602
Not yet available
Pathways
NETPATH
REACTOME
REACT_234105
Nuclear Receptor transcription pathway pathway
REACT_233572
Gene Expression pathway
REACT_206529
Generic Transcription Pathway pathway
KEGG
mmu03320
PPAR signaling pathway pathway
mmu05216
Thyroid cancer pathway
mmu05222
Small cell lung cancer pathway
mmu04920
Adipocytokine signaling pathway pathway
mmu05223
Non-small cell lung cancer pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15525
Nuclear Receptor transcription pathway pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_71
Gene Expression pathway
KEGG
hsa05223
Non-small cell lung cancer pathway
hsa05216
Thyroid cancer pathway
hsa05222
Small cell lung cancer pathway
hsa03320
PPAR signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G3UZ09 Q8VCR0
UniProt Splice Variant
Entrez Gene 20182
UniGene Mm.1243 Mm.411134
RefSeq NM_001205215 NM_001205214 NM_001205216 NM_011306
OMIM
CCDS CCDS57067 CCDS57066 CCDS57068
HPRD
IMGT
MGI ID MGI:98215
MGI Symbol Rxrb
EMBL AK140371 BC019432 CR974462
GenPept AAH19432 BAE24359
RNA Seq Atlas 20182

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca