InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hdac11

Summary

InnateDB Gene

IDBG-169921.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hdac11

Gene Name

histone deacetylase 11

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000034245

Encoded Proteins

IDBP-169923

histone deacetylase 11

IDBP-542687

histone deacetylase 11

IDBP-537676

histone deacetylase 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23980205

[Homo sapiens] MIR145 directly targets HDAC11 to promote IL10 expression in TLR4-triggered macrophages.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163517:
This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:91156665-91174692

Strand

Forward strand

Band

Transcripts

ENSMUST00000041736	ENSMUSP00000043828
ENSMUST00000154389
ENSMUST00000143621	ENSMUSP00000121624
ENSMUST00000127768
ENSMUST00000155007	ENSMUSP00000120923
ENSMUST00000134154

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004407	histone deacetylase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016787	hydrolase activity
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008152	metabolic process
GO:0014003	oligodendrocyte development
GO:0016568	chromatin modification
GO:0016575	histone deacetylation
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation