Mus musculus Gene: Tec | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-170167.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Tec | ||||||||||||||||||||||
Gene Name | tec protein tyrosine kinase | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000029217 | ||||||||||||||||||||||
Encoded Proteins |
tec protein tyrosine kinase
tec protein tyrosine kinase
tec protein tyrosine kinase
tec protein tyrosine kinase
tec protein tyrosine kinase
tec protein tyrosine kinase
tec protein tyrosine kinase
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135605:
The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 5:72755718-72868483 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | C3.2 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Innate Immune System pathway
Signaling by SCF-KIT pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
FCERI mediated Ca+2 mobilization pathway
Signaling by Interleukins pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signal Transduction pathway
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KEGG |
T cell receptor signaling pathway pathway
Osteoclast differentiation pathway
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INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
KitReceptor pathway
TCR pathway
BCR pathway
IL3 pathway
IL6 pathway
TSLP pathway
Prolactin pathway
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REACTOME |
Interleukin-3, 5 and GM-CSF signaling pathway
Signaling by SCF-KIT pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Immune System pathway
Signaling by Interleukins pathway
FCERI mediated Ca+2 mobilization pathway
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KEGG |
T cell receptor signaling pathway pathway
Osteoclast differentiation pathway
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INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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PID NCI |
EPO signaling pathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 21682 | ||||||||||||||||||||||
UniGene | Mm.319581 | ||||||||||||||||||||||
RefSeq | NM_001113460 NM_001113461 NM_001113464 NM_013689 XM_006503845 XM_006503846 XM_006503847 XM_006503849 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS51515 CCDS51516 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:98662 | ||||||||||||||||||||||
MGI Symbol | Tec | ||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 21682 | ||||||||||||||||||||||