InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: H2-DMa

Summary

InnateDB Gene

IDBG-170449.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H2-DMa

Gene Name

histocompatibility 2, class II, locus DMa

Synonyms

H-2Ma; H2-Ma

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037649

Encoded Proteins

IDBP-170451

histocompatibility 2, class II, locus DMa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204257:
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:34135182-34139101

Strand

Forward strand

Band

Transcripts

ENSMUST00000042121	ENSMUSP00000037088
ENSMUST00000173907

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0023026	MHC class II protein complex binding

Biological Process

GO:0002503	peptide antigen assembly with MHC class II protein complex
GO:0006461	protein complex assembly
GO:0006955	immune response
GO:0015031	protein transport
GO:0016064	immunoglobulin mediated immune response
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045059	positive thymic T cell selection
GO:0045582	positive regulation of T cell differentiation
GO:0048839	inner ear development
GO:0050778	positive regulation of immune response
GO:0051085	chaperone mediated protein folding requiring cofactor

Cellular Component

GO:0005622	intracellular
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005770	late endosome
GO:0005771	multivesicular body
GO:0009986	cell surface
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042613	MHC class II protein complex
GO:0070062	extracellular vesicular exosome