InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gapdhs

Summary

InnateDB Gene

IDBG-171174.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gapdhs

Gene Name

glyceraldehyde-3-phosphate dehydrogenase, spermatogenic

Synonyms

Gapd-s; Gapds

Species

Mus musculus

Ensembl Gene

ENSMUSG00000061099

Encoded Proteins

IDBP-171178

glyceraldehyde-3-phosphate dehydrogenase, spermatogenic

IDBP-787589

glyceraldehyde-3-phosphate dehydrogenase, spermatogenic

IDBP-787591

glyceraldehyde-3-phosphate dehydrogenase, spermatogenic

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105679:
This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:30729775-30743681

Strand

Reverse strand

Band

Transcripts

ENSMUST00000074758	ENSMUSP00000074317
ENSMUST00000182067	ENSMUSP00000138697
ENSMUST00000182634	ENSMUSP00000138634

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0005515	protein binding
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661	NADP binding
GO:0051287	NAD binding

Biological Process

GO:0006006	glucose metabolic process
GO:0006096	glycolytic process
GO:0007286	spermatid development
GO:0030317	sperm motility
GO:0045821	positive regulation of glycolytic process
GO:0055114	oxidation-reduction process