InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mgea5

Summary

InnateDB Gene

IDBG-171210.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mgea5

Gene Name

meningioma expressed antigen 5 (hyaluronidase)

Synonyms

2810009A20Rik; 4833427O07Rik; 5830447M11Rik; AA408215; Hy5; mKIAA0679; Ncoat

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025220

Encoded Proteins

IDBP-171212

meningioma expressed antigen 5 (hyaluronidase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198408:
The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:45750261-45783520

Strand

Reverse strand

Band

Transcripts

ENSMUST00000026243

ENSMUSP00000026243

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004402	histone acetyltransferase activity
GO:0016798	hydrolase activity, acting on glycosyl bonds

Biological Process

GO:0006044	N-acetylglucosamine metabolic process
GO:0006612	protein targeting to membrane
GO:0007568	aging
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0010616	negative regulation of cardiac muscle adaptation
GO:0016573	histone acetylation
GO:0031343	positive regulation of cell killing
GO:0032024	positive regulation of insulin secretion
GO:0043243	positive regulation of protein complex disassembly
GO:0045862	positive regulation of proteolysis
GO:0046060	dATP metabolic process
GO:0046326	positive regulation of glucose import
GO:0048545	response to steroid hormone
GO:0051054	positive regulation of DNA metabolic process
GO:0051901	positive regulation of mitochondrial depolarization
GO:0051928	positive regulation of calcium ion transport
GO:0060051	negative regulation of protein glycosylation
GO:0060124	positive regulation of growth hormone secretion
GO:0070265	necrotic cell death

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000198408

View Gene Order

ENSBTAG00000016336

Not yet available

Cross-References

SwissProt

Q9EQQ9

TrEMBL

Q9CU60

UniProt Splice Variant

Entrez Gene

76055

UniGene

Mm.122725 Mm.396687 Mm.490674

RefSeq

NM_023799

OMIM

CCDS

CCDS29866

HPRD

IMGT

MGI ID

MGI:1932139

MGI Symbol

Mgea5

EMBL

AF132214 AK012695 AK014781 AK017997 AK077613 AK088774 AK129188 AK145227 BC041109 BC054821

GenPept

AAG43273 AAH41109 AAH54821 BAB28416 BAB29550 BAB31029 BAC36900 BAC40564 BAC97998 BAE26311

RNA Seq Atlas

76055