Mus musculus Gene: Cd22
Summary
InnateDB Gene IDBG-171574.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd22
Gene Name CD22 antigen
Synonyms A530093D23; Lyb-8; Lyb8
Species Mus musculus
Ensembl Gene ENSMUSG00000030577
Encoded Proteins
CD22 antigen
CD22 antigen
CD22 antigen
CD22 antigen
CD22 antigen
CD22 antigen
CD22 antigen
CD22 antigen
CD22 antigen
CD22 antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] CD22 (Siglec-2), like other sialic acid-binding immunoglobulin-like lectins (siglecs), is predominately expressed on immune cells. CD22 exhibits hallmarks of clathrin-mediated endocytosis and traffics to recycling compartment, reflecting its role in cell signalling and innate immunity.
[Homo sapiens] CD22 expression and function are differentially regulated in B-1 and conventional B-2 cells, which are implicated in innate and adaptive immunity, respectively.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000012124:
Gene Information
Type Protein coding
Genomic Location Chromosome 7:30865402-30880342
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000019248 ENSMUSP00000019248
ENSMUST00000108125 ENSMUSP00000103760
ENSMUST00000190646 ENSMUSP00000140528
ENSMUST00000186154 ENSMUSP00000139685
ENSMUST00000189718 ENSMUSP00000140521
ENSMUST00000190617 ENSMUSP00000139871
ENSMUST00000187989 ENSMUSP00000141178
ENSMUST00000190455 ENSMUSP00000140357
ENSMUST00000186354
ENSMUST00000188157 ENSMUSP00000140450
ENSMUST00000187585
ENSMUST00000190170
ENSMUST00000186333
ENSMUST00000190753 ENSMUSP00000140014
ENSMUST00000187436
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015026 coreceptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Cell adhesion molecules (CAMs) pathway
Hematopoietic cell lineage pathway
B cell receptor signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
BCR pathway
REACTOME
KEGG
Hematopoietic cell lineage pathway
Cell adhesion molecules (CAMs) pathway
B cell receptor signaling pathway pathway
INOH
PID NCI
BCR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001043317 NM_009845 XM_006539489 XM_006539490 XM_006539491 XM_006539492 XM_006539493 XM_006539494 XM_006539495
OMIM
CCDS CCDS21114
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas