Version 5.4
Mus musculus Gene: Msh3
Summary
InnateDB Gene IDBG-171801.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Msh3
Gene Name mutS homolog 3 (E. coli)
Synonyms D13Em1; Rep-3; Rep3
Species Mus musculus
Ensembl Gene ENSMUSG00000014850
Encoded Proteins
IDBP-171803
mutS homolog 3 (E. coli)
IDBP-787923
mutS homolog 3 (E. coli)
IDBP-787925
mutS homolog 3 (E. coli)
IDBP-787926
mutS homolog 3 (E. coli)
IDBP-787927
mutS homolog 3 (E. coli)
IDBP-787928
mutS homolog 3 (E. coli)
IDBP-787929
mutS homolog 3 (E. coli)
IDBP-787930
mutS homolog 3 (E. coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113318:
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:92211872-92355003
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000022220 ENSMUSP00000022220
ENSMUST00000185852 ENSMUSP00000140002
ENSMUST00000191242
ENSMUST00000191304
ENSMUST00000191550 ENSMUSP00000140659
ENSMUST00000186392
ENSMUST00000190761 ENSMUSP00000140402
ENSMUST00000187874 ENSMUSP00000139620
ENSMUST00000190462
ENSMUST00000191509 ENSMUSP00000141158
ENSMUST00000189376
ENSMUST00000187831
ENSMUST00000186878
ENSMUST00000190393 ENSMUSP00000141163
ENSMUST00000187424 ENSMUSP00000139622
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000403 Y-form DNA binding
GO:0000404 heteroduplex DNA loop binding
GO:0000406 double-strand/single-strand DNA junction binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 DNA-dependent ATPase activity
GO:0019237 centromeric DNA binding
GO:0019899 enzyme binding
GO:0030983 mismatched DNA binding
GO:0032139 dinucleotide insertion or deletion binding
GO:0032142 single guanine insertion binding
GO:0032181 dinucleotide repeat insertion binding
GO:0032357 oxidized purine DNA binding
Biological Process
GO:0000710 meiotic mismatch repair
GO:0006200 ATP catabolic process
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0007131 reciprocal meiotic recombination
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0043570 maintenance of DNA repeat elements
GO:0045910 negative regulation of DNA recombination
GO:0051096 positive regulation of helicase activity
Cellular Component
GO:0000228 nuclear chromosome
GO:0005634 nucleus
GO:0016020 membrane
GO:0032302 MutSbeta complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000113318
View Gene Order
ENSBTAG00000007684
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05210
Colorectal cancer pathway
mmu03430
Mismatch repair pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
REACT_228013
Mismatch Repair pathway
REACT_216
DNA Repair pathway
KEGG
hsa05210
Colorectal cancer pathway
hsa03430
Mismatch repair pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_010829 XM_006517541 XM_006517542 XM_006517543 XM_006517547
OMIM
CCDS CCDS49326
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca