Version 5.4
Mus musculus Gene: Sept8
Summary
InnateDB Gene IDBG-171841.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sept8
Gene Name septin 8
Synonyms AW046166; mKIAA0202; Sepl
Species Mus musculus
Ensembl Gene ENSMUSG00000018398
Encoded Proteins
IDBP-263316
septin 8
IDBP-400587
septin 8
IDBP-400588
septin 8
IDBP-400585
septin 8
IDBP-540577
septin 8
IDBP-533418
septin 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164402:
This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. [provided by RefSeq, Jun 2012]
This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:53519257-53549565
Strand Forward strand
Band B1.3
Transcripts
ENSMUST00000108987 ENSMUSP00000104615
ENSMUST00000121334 ENSMUSP00000113038
ENSMUST00000120878 ENSMUSP00000113775
ENSMUST00000117061 ENSMUSP00000112920
ENSMUST00000142800 ENSMUSP00000124057
ENSMUST00000147912 ENSMUSP00000120427
ENSMUST00000145927
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0007049 cell cycle
GO:0008150 biological_process
Cellular Component
GO:0005737 cytoplasm
GO:0031105 septin complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164402
View Gene Order
ENSBTAG00000008609
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B1AQY9 E0CYM4
UniProt Splice Variant
Entrez Gene 20362
UniGene Mm.274399 Mm.359575 Mm.397763 Mm.409093
RefSeq NM_001252332 NM_001252333 NM_033144 XM_006532633 XM_006532634
OMIM
CCDS CCDS48794 CCDS56768
HPRD
IMGT
MGI ID MGI:894310
MGI Symbol Sept8
EMBL AL596095
GenPept
RNA Seq Atlas 20362

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca