Version 5.4
Mus musculus Gene: Abca7
Summary
InnateDB Gene IDBG-171979.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Abca7
Gene Name ATP-binding cassette, sub-family A (ABC1), member 7
Synonyms Abc51; ABCX
Species Mus musculus
Ensembl Gene ENSMUSG00000035722
Encoded Proteins
IDBP-171981
ATP-binding cassette, sub-family A (ABC1), member 7
IDBP-540561
ATP-binding cassette, sub-family A (ABC1), member 7
IDBP-621646
ATP-binding cassette, sub-family A (ABC1), member 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is widely expressed with highest detection in spleen and hematopoietic tissues. The function of this protein has not yet been determined; however, a related human protein is thought to play a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:79996494-80015572
Strand Forward strand
Band C1
Transcripts
ENSMUST00000043866 ENSMUSP00000043090
ENSMUST00000132517 ENSMUSP00000115111
ENSMUST00000171637 ENSMUSP00000128121
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005548 phospholipid transporter activity
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0034188 apolipoprotein A-I receptor activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006909 phagocytosis
GO:0007613 memory
GO:0010875 positive regulation of cholesterol efflux
GO:0017121 phospholipid scrambling
GO:0018149 peptide cross-linking
GO:0032780 negative regulation of ATPase activity
GO:0032781 positive regulation of ATPase activity
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034380 high-density lipoprotein particle assembly
GO:0034504 protein localization to nucleus
GO:0038027 apolipoprotein A-I-mediated signaling pathway
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process
GO:0050766 positive regulation of phagocytosis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:1900223 positive regulation of beta-amyloid clearance
GO:1901076 positive regulation of engulfment of apoptotic cell
GO:1902430 negative regulation of beta-amyloid formation
GO:1902995 positive regulation of phospholipid efflux
Cellular Component
GO:0000139 Golgi membrane
GO:0001891 phagocytic cup
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0032587 ruffle membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000064687
View Gene Order
ENSBTAG00000020766
Not yet available
Pathways
NETPATH
REACTOME
REACT_197984
ABCA transporters in lipid homeostasis pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_237882
ABC-family proteins mediated transport pathway
KEGG
mmu02010
ABC transporters pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111158
ABCA transporters in lipid homeostasis pathway
REACT_15480
ABC-family proteins mediated transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
KEGG
hsa02010
ABC transporters pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.103351
RefSeq NM_013850 XM_006513710 XM_006513712 XM_006513713 XM_006513714
OMIM
CCDS CCDS24004
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca