InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Zfyve16

Summary

InnateDB Gene

IDBG-172128.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zfyve16

Gene Name

zinc finger, FYVE domain containing 16

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021706

Encoded Proteins

IDBP-172130

zinc finger, FYVE domain containing 16

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000039319:
The ZFYVE16 gene encodes endofin, an endosomal protein implicated in regulating membrane trafficking. It is characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of the molecule (Seet et al., 2004 [PubMed 14613930]).[supplied by OMIM, Mar 2008]
This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:92487108-92530868

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022217	ENSMUSP00000022217
ENSMUST00000156586
ENSMUST00000136135
ENSMUST00000154850

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005545	1-phosphatidylinositol binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008565	protein transporter activity
GO:0046872	metal ion binding

Biological Process

GO:0006622	protein targeting to lysosome
GO:0016197	endosomal transport

Cellular Component

GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0031901	early endosome membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000039319

View Gene Order

ENSBTAG00000021577

Not yet available

Pathways

NETPATH

REACTOME

REACT_220505

Signaling by BMP pathway

REACT_188257

Signal Transduction pathway

KEGG

mmu04350

TGF-beta signaling pathway pathway

mmu04144

Endocytosis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

NetPath_7

TGF_beta_Receptor pathway

REACTOME

REACT_12034

Signaling by BMP pathway

REACT_111102

Signal Transduction pathway

KEGG

hsa04350

TGF-beta signaling pathway pathway

hsa04144

Endocytosis pathway

INOH

PID NCI

bmppathway

BMP receptor signaling

tgfbrpathway

TGF-beta receptor signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.259585

RefSeq

NM_173392

OMIM

CCDS

CCDS26682

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas