Version 5.4
Mus musculus Gene: Pkn1
Summary
InnateDB Gene IDBG-172377.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pkn1
Gene Name protein kinase N1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000057672
Encoded Proteins
IDBP-172379
protein kinase N1
IDBP-535794
protein kinase N1
IDBP-534886
protein kinase N1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18429822
[Homo sapiens] PKN1 is a ubiquitously expressed kinase that, when phosphorylated by TRAF1, plays a critical role in the negative regulation of tonic activity of JNK and NF-kappaB signalling pathways.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123143:
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:83669762-83699179
Strand Reverse strand
Band C2
Transcripts
ENSMUST00000005616 ENSMUSP00000005616
ENSMUST00000144258 ENSMUSP00000116235
ENSMUST00000132945 ENSMUSP00000115054
ENSMUST00000128523
ENSMUST00000138898
ENSMUST00000124946
ENSMUST00000146057
ENSMUST00000133195
ENSMUST00000135356
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004713 protein tyrosine kinase activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017049 GTP-Rho binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0035402 histone kinase activity (H3-T11 specific)
GO:0042393 histone binding
GO:0042826 histone deacetylase binding
GO:0048365 Rac GTPase binding
GO:0050681 androgen receptor binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0006972 hyperosmotic response
GO:0007165 signal transduction
GO:0010631 epithelial cell migration
GO:0035407 histone H3-T11 phosphorylation
GO:2000145 regulation of cell motility
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030496 midbody
GO:0032154 cleavage furrow
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000123143
View Gene Order
ENSBTAG00000017037
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
p38gammadeltapathway
Signaling mediated by p38-gamma and p38-delta
thrombin_par1_pathway
PAR1-mediated thrombin signaling events
rhoa_pathway
RhoA signaling pathway
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.213000 Mm.417343
RefSeq NM_001199593 NM_177262 XM_006531110
OMIM
CCDS CCDS22459 CCDS57627
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca