InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Scn1b

Summary

InnateDB Gene

IDBG-172430.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scn1b

Gene Name

sodium channel, voltage-gated, type I, beta

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019194

Encoded Proteins

IDBP-172432

sodium channel, voltage-gated, type I, beta

IDBP-790350

sodium channel, voltage-gated, type I, beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105711:
Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:31116524-31126945

Strand

Reverse strand

Band

Transcripts

ENSMUST00000098548	ENSMUSP00000096148
ENSMUST00000188002	ENSMUSP00000139680
ENSMUST00000187469

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005248	voltage-gated sodium channel activity
GO:0005515	protein binding
GO:0017080	sodium channel regulator activity
GO:0019871	sodium channel inhibitor activity
GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential
GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential

Biological Process

GO:0002028	regulation of sodium ion transport
GO:0007411	axon guidance
GO:0010765	positive regulation of sodium ion transport
GO:0010976	positive regulation of neuron projection development
GO:0019227	neuronal action potential propagation
GO:0021966	corticospinal neuron axon guidance
GO:0035725	sodium ion transmembrane transport
GO:0040011	locomotion
GO:0046684	response to pyrethroid
GO:0051899	membrane depolarization
GO:0060048	cardiac muscle contraction
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization
GO:0061337	cardiac conduction
GO:0086002	cardiac muscle cell action potential involved in contraction
GO:0086012	membrane depolarization during cardiac muscle cell action potential
GO:0086047	membrane depolarization during Purkinje myocyte cell action potential
GO:0086091	regulation of heart rate by cardiac conduction
GO:2000649	regulation of sodium ion transmembrane transporter activity