Version 5.4
Mus musculus Gene: Setdb1
Summary
InnateDB Gene IDBG-172468.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Setdb1
Gene Name SET domain, bifurcated 1
Synonyms AU022152; ESET; KMT1E; mKIAA0067
Species Mus musculus
Ensembl Gene ENSMUSG00000015697
Encoded Proteins
IDBP-172470
SET domain, bifurcated 1
IDBP-267229
SET domain, bifurcated 1
IDBP-267231
SET domain, bifurcated 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143379:
This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:95323525-95357202
Strand Reverse strand
Band F2.1
Transcripts
ENSMUST00000015841 ENSMUSP00000015841
ENSMUST00000107171 ENSMUSP00000102789
ENSMUST00000107170 ENSMUSP00000102788
ENSMUST00000124638
ENSMUST00000132468
ENSMUST00000152260
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 113 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 13 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 113 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0018024 histone-lysine N-methyltransferase activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001833 inner cell mass cell proliferation
GO:0034968 histone lysine methylation
GO:0036124 histone H3-K9 trimethylation
GO:0060348 bone development
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000143379
View Gene Order
ENSBTAG00000000098
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00310
Lysine degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_8
Wnt pathway
REACTOME
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
wnt_noncanonical_pathway
Noncanonical Wnt signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.490259
RefSeq NM_001163641 NM_001163642 NM_018877
OMIM
CCDS CCDS17613 CCDS50991
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca