Version 5.4
Mus musculus Gene: Cdc42bpb
Summary
InnateDB Gene IDBG-172723.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdc42bpb
Gene Name CDC42 binding protein kinase beta
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000021279
Encoded Proteins
IDBP-172725
CDC42 binding protein kinase beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198752:
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:111292972-111377718
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000041965 ENSMUSP00000042565
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017048 Rho GTPase binding
Biological Process
GO:0006468 protein phosphorylation
GO:0016477 cell migration
GO:0030036 actin cytoskeleton organization
GO:0031032 actomyosin structure organization
GO:0031532 actin cytoskeleton reorganization
GO:0035556 intracellular signal transduction
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0031252 cell leading edge
GO:0042641 actomyosin
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198752
View Gene Order
ENSBTAG00000016456
Not yet available
Cross-References
SwissProt Q7TT50
TrEMBL
UniProt Splice Variant
Entrez Gene 217866
UniGene Mm.485798
RefSeq NM_183016
OMIM
CCDS CCDS26176
HPRD
IMGT
MGI ID MGI:2136459
MGI Symbol Cdc42bpb
EMBL AC127580 AK173103 AY277589 BC049921
GenPept AAH49921 AAP34402 BAD32381
RNA Seq Atlas 217866

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca