Homo sapiens Gene: FZR1
Summary
InnateDB Gene IDBG-17274.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FZR1
Gene Name fizzy/cell division cycle 20 related 1 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000105325
Encoded Proteins
fizzy/cell division cycle 20 related 1 (Drosophila)
fizzy/cell division cycle 20 related 1 (Drosophila)
fizzy/cell division cycle 20 related 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:3506273-3538330
Strand Forward strand
Band p13.3
Transcripts
ENST00000313639 ENSP00000321800
ENST00000395095 ENSP00000378529
ENST00000441788 ENSP00000410369
ENST00000586212
ENST00000592214
ENST00000588327
ENST00000591290 ENSP00000467967
ENST00000588084
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 123 [view]
Protein-Protein 123 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006281 DNA repair
GO:0007067 mitotic nuclear division
GO:0008284 positive regulation of cell proliferation
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031572 G2 DNA damage checkpoint
GO:0040020 regulation of meiosis
GO:0045732 positive regulation of protein catabolic process
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051488 activation of anaphase-promoting complex activity
GO:0070306 lens fiber cell differentiation
GO:0070979 protein K11-linked ubiquitination
GO:0090344 negative regulation of cell aging
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005680 anaphase-promoting complex
GO:0005829 cytosol
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TGF_beta_Receptor pathway
REACTOME
DNA Replication pathway
Cellular responses to stress pathway
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
Phosphorylation of Emi1 pathway
Synthesis of DNA pathway
APC/C-mediated degradation of cell cycle proteins pathway
SCF-beta-TrCP mediated degradation of Emi1 pathway
Regulation of mitotic cell cycle pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
S Phase pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Cell Cycle pathway
Adaptive Immune System pathway
Removal of licensing factors from origins pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Cellular Senescence pathway
Switching of origins to a post-replicative state pathway
Orc1 removal from chromatin pathway
Cell Cycle, Mitotic pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Class I MHC mediated antigen processing & presentation pathway
Regulation of DNA replication pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
KEGG
Cell cycle pathway
Ubiquitin mediated proteolysis pathway
Progesterone-mediated oocyte maturation pathway
INOH
PID BIOCARTA
PID NCI
Aurora A signaling
PLK1 signaling events
Cross-References
SwissProt Q9UM11
TrEMBL
UniProt Splice Variant
Entrez Gene 51343
UniGene Hs.413133
RefSeq NM_001136198 XM_005259573 NM_001136197 NM_016263 XM_006722764
HUGO HGNC:24824
OMIM 603619
CCDS CCDS45916 CCDS12109 CCDS45917
HPRD 04687
IMGT
EMBL AB013462 AB013463 AB033068 AC005786 AC005787 AF080397 AF083810 AF102507 AF102508 AF433157 BC013413 BT007115
GenPept AAC62835 AAC62836 AAD26623 AAD26624 AAD52030 AAF20266 AAH13413 AAL28117 AAP35779 BAA86556 BAA86954 BAA86955
RNA Seq Atlas 51343