Mus musculus Gene: Ctss | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-172850.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Ctss | ||||||||||||||||||||||
Gene Name | cathepsin S | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000038642 | ||||||||||||||||||||||
Encoded Proteins |
cathepsin S
cathepsin S
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
Ctss is an endosomal and lysosomal protease that is upregulated during various inflammatory disorders. Tlr2, 3, 4 ligand engagement increases the proteolytic activities of Ctss in macrophages.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Homo sapiens] CTSS is a member of the Cathepsins protein family, which are key modulators of cell death and inflammatory responses.
[Homo sapiens] CTSS is an endosomal and lysosomal protease that is upregulated during various inflammatory disorders. TLR2, 3, 4 ligand engagement increases the proteolytic activities of CTSS in macrophages. (Demonstrated in murine model)
[Homo sapiens] Cleavage of CAMP by cathepsins CTSS and CTSK impairs its antimicrobial activity against Pseudomonas aeruginosa and Staphylococcus aureus.
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Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163131:
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 3:95526786-95556403 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | F2.1 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Collagen formation pathway
Assembly of collagen fibrils and other multimeric structures pathway
Innate Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
Trafficking and processing of endosomal TLR pathway
Immune System pathway
Extracellular matrix organization pathway
Endosomal/Vacuolar pathway pathway
MHC class II antigen presentation pathway
Toll-Like Receptors Cascades pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Degradation of the extracellular matrix pathway
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KEGG |
Antigen processing and presentation pathway
Lysosome pathway
Phagosome pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Endosomal/Vacuolar pathway pathway
Trafficking and processing of endosomal TLR pathway
MHC class II antigen presentation pathway
Assembly of collagen fibrils and other multimeric structures pathway
Extracellular matrix organization pathway
Innate Immune System pathway
Degradation of the extracellular matrix pathway
Toll-Like Receptors Cascades pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
Collagen formation pathway
Collagen formation pathway
Extracellular matrix organization pathway
Class I MHC mediated antigen processing & presentation pathway
Trafficking and processing of endosomal TLR pathway
Immune System pathway
Degradation of the extracellular matrix pathway
Assembly of collagen fibrils and other multimeric structures pathway
Toll-Like Receptors Cascades pathway
MHC class II antigen presentation pathway
Endosomal/Vacuolar pathway pathway
Adaptive Immune System pathway
Innate Immune System pathway
Antigen processing-Cross presentation pathway
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KEGG |
Antigen processing and presentation pathway
Lysosome pathway
Phagosome pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | O70370 | ||||||||||||||||||||||
TrEMBL | F6WR04 Q3UBR4 Q3UD32 Q8BSZ5 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 13040 | ||||||||||||||||||||||
UniGene | Mm.3619 Mm.402416 | ||||||||||||||||||||||
RefSeq | NM_001267695 NM_021281 XM_006500975 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS50992 CCDS71291 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:107341 | ||||||||||||||||||||||
MGI Symbol | Ctss | ||||||||||||||||||||||
EMBL | AC092203 AF038546 AF051726 AF051727 AF051728 AF051729 AF051730 AF051731 AF051732 AJ002386 AJ223208 AK028366 AK150274 AK150758 AK150842 AK152618 CH466620 Y18466 | ||||||||||||||||||||||
GenPept | AAB94925 AAC05781 BAC25906 BAE29430 BAE29827 BAE29900 BAE31361 CAA05360 CAA11182 CAA77184 EDL38819 | ||||||||||||||||||||||
RNA Seq Atlas | 13040 | ||||||||||||||||||||||