Version 5.4
Mus musculus Gene: App
Summary
InnateDB Gene IDBG-172954.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol App
Gene Name amyloid beta (A4) precursor protein
Synonyms Abeta; Abpp; Adap; Ag; betaApp; Cvap; E030013M08Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000022892
Encoded Proteins
IDBP-172956
amyloid beta (A4) precursor protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142192:
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:84954440-85173707
Strand Reverse strand
Band C3.3
Transcripts
ENSMUST00000005406 ENSMUSP00000005406
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 1813 interaction(s) predicted by orthology.
Experimentally validated
Total 63 [view]
Protein-Protein 57 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1813 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0016504 peptidase activator activity
GO:0019899 enzyme binding
GO:0033130 acetylcholine receptor binding
GO:0042802 identical protein binding
GO:0046914 transition metal ion binding
GO:0051425 PTB domain binding
GO:0070851 growth factor receptor binding
Biological Process
GO:0001967 suckling behavior
GO:0006378 mRNA polyadenylation
GO:0006417 regulation of translation
GO:0006468 protein phosphorylation
GO:0006878 cellular copper ion homeostasis
GO:0006897 endocytosis
GO:0006979 response to oxidative stress
GO:0007155 cell adhesion
GO:0007176 regulation of epidermal growth factor-activated receptor activity
GO:0007219 Notch signaling pathway
GO:0007409 axonogenesis
GO:0007617 mating behavior
GO:0007626 locomotory behavior
GO:0008088 axon cargo transport
GO:0008203 cholesterol metabolic process
GO:0008344 adult locomotory behavior
GO:0008542 visual learning
GO:0010468 regulation of gene expression
GO:0010951 negative regulation of endopeptidase activity
GO:0010952 positive regulation of peptidase activity
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0016199 axon midline choice point recognition
GO:0016322 neuron remodeling
GO:0016358 dendrite development
GO:0030198 extracellular matrix organization
GO:0030900 forebrain development
GO:0031175 neuron projection development
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0040014 regulation of multicellular organism growth
GO:0043393 regulation of protein binding
GO:0045665 negative regulation of neuron differentiation
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048669 collateral sprouting in absence of injury
GO:0050803 regulation of synapse structure and activity
GO:0050885 neuromuscular process controlling balance
GO:0051124 synaptic growth at neuromuscular junction
GO:0051260 protein homooligomerization
GO:0051402 neuron apoptotic process
GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis
Cellular Component
GO:0005615 extracellular space
GO:0005641 nuclear envelope lumen
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0005911 cell-cell junction
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030134 ER to Golgi transport vesicle
GO:0030424 axon
GO:0031410 cytoplasmic vesicle
GO:0031594 neuromuscular junction
GO:0035253 ciliary rootlet
GO:0043005 neuron projection
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0043231 intracellular membrane-bounded organelle
GO:0043235 receptor complex
GO:0045121 membrane raft
GO:0045177 apical part of cell
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
GO:0051233 spindle midzone
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000142192
View Gene Order
ENSBTAG00000017753
Not yet available
Pathways
NETPATH
REACTOME
REACT_202898
TRAF6 mediated NF-kB activation pathway
REACT_230203
Platelet degranulation pathway
REACT_263316
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_229712
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_263004
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_223625
GPCR downstream signaling pathway
REACT_189085
Disease pathway
REACT_224553
Hemostasis pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_245896
MyD88 cascade initiated on plasma membrane pathway
REACT_198563
Amyloids pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_255939
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_215863
ZBP1(DAI) mediated induction of type I IFNs pathway
REACT_230745
Immune System pathway
REACT_206066
Extracellular matrix organization pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_260773
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_254406
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_198644
The NLRP3 inflammasome pathway
REACT_198647
Advanced glycosylation endproduct receptor signaling pathway
REACT_249409
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_198656
Inflammasomes pathway
REACT_231468
GPCR ligand binding pathway
REACT_235286
Peptide ligand-binding receptors pathway
REACT_202555
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_256727
MyD88 dependent cascade initiated on endosome pathway
REACT_218897
Cytosolic sensors of pathogen-associated DNA pathway
REACT_250376
G alpha (i) signalling events pathway
REACT_222971
RIP-mediated NFkB activation via ZBP1 pathway
REACT_196606
ECM proteoglycans pathway
REACT_206758
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
REACT_241786
MyD88-independent cascade pathway
REACT_188257
Signal Transduction pathway
REACT_219118
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_242921
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_230045
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_238546
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_219800
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
REACT_229705
Formyl peptide receptors bind formyl peptides and many other ligands pathway
REACT_261340
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
mmu05010
Alzheimer's disease pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_3
Notch pathway
NetPath_4
EGFR1 pathway
REACTOME
REACT_118563
RIP-mediated NFkB activation via ZBP1 pathway
REACT_118764
ZBP1(DAI) mediated induction of type I IFNs pathway
REACT_24969
TRAF6 mediated NF-kB activation pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_25195
Advanced glycosylation endproduct receptor signaling pathway
REACT_21281
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_75808
The NLRP3 inflammasome pathway
REACT_75900
Inflammasomes pathway
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_21264
Formyl peptide receptors bind formyl peptides and many other ligands pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_75925
Amyloids pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_118779
Extracellular matrix organization pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_75913
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_163773
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
REACT_6900
Immune System pathway
REACT_163906
ECM proteoglycans pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_21340
GPCR ligand binding pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
REACT_202252
Platelet degranulation pathway
REACT_218237
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_210286
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_205036
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_224703
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_205369
Signaling by GPCR pathway
REACT_205566
Activated TLR4 signalling pathway
REACT_222278
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_224546
MyD88-independent cascade pathway
REACT_209119
Inflammasomes pathway
REACT_220974
Cytosolic sensors of pathogen-associated DNA pathway
REACT_206540
Amyloids pathway
REACT_218317
The NLRP3 inflammasome pathway
REACT_217035
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_223425
Extracellular matrix organization pathway
REACT_221101
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_227345
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_210224
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_218118
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
REACT_212196
Hemostasis pathway
REACT_213138
Immune System pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_212308
Response to elevated platelet cytosolic Ca2+ pathway
REACT_210568
G alpha (i) signalling events pathway
REACT_219220
Toll-Like Receptors Cascades pathway
REACT_214353
Signal Transduction pathway
REACT_207058
TRAF6 mediated NF-kB activation pathway
REACT_219947
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_223848
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_225653
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_204725
Advanced glycosylation endproduct receptor signaling pathway
REACT_209521
G alpha (q) signalling events pathway
REACT_218091
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_214436
GPCR downstream signaling pathway
REACT_216676
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_219586
MyD88 dependent cascade initiated on endosome pathway
REACT_222217
ECM proteoglycans pathway
REACT_217214
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
REACT_216714
Innate Immune System pathway
REACT_209403
ZBP1(DAI) mediated induction of type I IFNs pathway
REACT_215391
RIP-mediated NFkB activation via ZBP1 pathway
REACT_207087
Disease pathway
REACT_211704
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_217527
MyD88 cascade initiated on plasma membrane pathway
KEGG
hsa05010
Alzheimer's disease pathway
INOH
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
glypican_1pathway
Glypican 1 network
p75ntrpathway
p75(NTR)-mediated signaling
Cross-References
SwissProt P12023
TrEMBL Q6GR78 Q8BPV5 Q9QX46
UniProt Splice Variant
Entrez Gene 11820
UniGene Mm.472971 Mm.490986
RefSeq NM_001198823 NM_001198824 NM_001198825 NM_001198826 NM_007471
OMIM
CCDS CCDS28285
HPRD
IMGT
MGI ID MGI:88059
MGI Symbol App
EMBL AH008875 AK052448 AK147543 BC005490 BC070409 CH466521 D10603 M18373 M24397 U82624 U84012 X15210 X59379
GenPept AAA37139 AAA39929 AAB40919 AAB41502 AAF20194 AAH05490 AAH70409 BAA01456 BAC34997 BAE27986 CAA33280 EDK98319
RNA Seq Atlas 11820

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca