Version 5.4
| Mus musculus Gene: Prkaca | |||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-173105.6 | ||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||
| Gene Symbol | Prkaca | ||||||||||||||||||||||||||||||||||
| Gene Name | protein kinase, cAMP dependent, catalytic, alpha | ||||||||||||||||||||||||||||||||||
| Synonyms | Pkaca; PKCD | ||||||||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000005469 | ||||||||||||||||||||||||||||||||||
| Encoded Proteins |
protein kinase, cAMP dependent, catalytic, alpha
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| Protein Structure | |||||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] MAP3K7 (TAK1) Ser412 phosphorylation is regulated by PRKACA and PRKX, and is essential for proper signalling, as well as proinflammatory cytokine induction by TLR/IL-1R activation.
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| Entrez Gene | |||||||||||||||||||||||||||||||||||
| Summary |
This gene encodes a member of the serine/threonine protein kinase family. The holoenzyme, protein kinase A (also known as cyclic-AMP dependent protein kinase), mediates cellular response to changes in cyclic-AMP levels. This gene encodes the alpha catalytic subunit of protein kinase A. Protein kinase A-mediated signaling is transduced via phosphorylation of target proteins, and is important for many cellular functions, including mammalian sperm maturation and motility. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Apr 2013] |
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| Gene Information | |||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 8:83972978-83996445 | ||||||||||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||||||||||
| Band | C2 | ||||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 70 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||
| REACTOME |
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Innate Immune System pathway
G2/M Transition pathway
Signaling by ERBB2 pathway
PLCG1 events in ERBB2 signaling pathway
Cell Cycle, Mitotic pathway
Disease pathway
Hemostasis pathway
Signaling by GPCR pathway
Glucagon signaling in metabolic regulation pathway
Hedgehog 'off' state pathway
Integration of energy metabolism pathway
Loss of Nlp from mitotic centrosomes pathway
Ca-dependent events pathway
Signaling by FGFR in disease pathway
DARPP-32 events pathway
Cytokine Signaling in Immune system pathway
PLC-gamma1 signalling pathway
PKA-mediated phosphorylation of CREB pathway
Cell Cycle pathway
Glucose metabolism pathway
Metabolism pathway
PKA activation in glucagon signalling pathway
Immune System pathway
EGFR interacts with phospholipase C-gamma pathway
Metabolism of lipids and lipoproteins pathway
Aquaporin-mediated transport pathway
Regulation of insulin secretion pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
CaM pathway pathway
Lipid digestion, mobilization, and transport pathway
Factors involved in megakaryocyte development and platelet production pathway
Mitotic G2-G2/M phases pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
Degradation of GLI2 by the proteasome pathway
Signaling by EGFR pathway
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
Degradation of GLI1 by the proteasome pathway
GLI3 is processed to GLI3R by the proteasome pathway
Rap1 signalling pathway
Phospholipase C-mediated cascade pathway
Signaling by Interleukins pathway
Gluconeogenesis pathway
Transmembrane transport of small molecules pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Glycogen storage diseases pathway
PKA-mediated phosphorylation of key metabolic factors pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
DAG and IP3 signaling pathway
Signaling by Hedgehog pathway
NGF signalling via TRKA from the plasma membrane pathway
Opioid Signalling pathway
Calmodulin induced events pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signal Transduction pathway
Signaling by FGFR pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
PLC beta mediated events pathway
G-protein mediated events pathway
Myoclonic epilepsy of Lafora pathway
Signaling by EGFR in Cancer pathway
PKA activation pathway
Metabolism of carbohydrates pathway
Centrosome maturation pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
Taste transduction pathway
Olfactory transduction pathway
Insulin signaling pathway pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Wnt signaling pathway pathway
Gap junction pathway
GnRH signaling pathway pathway
MAPK signaling pathway pathway
Long-term potentiation pathway
Hedgehog signaling pathway pathway
Apoptosis pathway
Parkinson's disease pathway
Chemokine signaling pathway pathway
Vascular smooth muscle contraction pathway
Prion diseases pathway
Dilated cardiomyopathy pathway
Progesterone-mediated oocyte maturation pathway
Oocyte meiosis pathway
Vasopressin-regulated water reabsorption pathway
Amoebiasis pathway
Gastric acid secretion pathway
Salivary secretion pathway
Bile secretion pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
VEGF signaling pathway pathway
GPCR Dopamine D1like receptor signaling pathway pathway
GPCR signaling pathway
Hedgehog signaling pathway pathway
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| PID NCI | |||||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||
| NETPATH |
Wnt pathway
Hedgehog pathway
IL3 pathway
TSH pathway
FSH pathway
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| REACTOME |
Regulation of PLK1 Activity at G2/M Transition pathway
Loss of Nlp from mitotic centrosomes pathway
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
Recruitment of mitotic centrosome proteins and complexes pathway
PKA activation pathway
PKA-mediated phosphorylation of CREB pathway
Calmodulin induced events pathway
CaM pathway pathway
DAG and IP3 signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Rap1 signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Factors involved in megakaryocyte development and platelet production pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
PLC-gamma1 signalling pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by EGFR pathway
PLC beta mediated events pathway
DARPP-32 events pathway
Opioid Signalling pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Phospholipase C-mediated cascade pathway
Signaling by FGFR pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
Gluconeogenesis pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Regulation of insulin secretion pathway
PKA activation in glucagon signalling pathway
Glucagon signaling in metabolic regulation pathway
PKA-mediated phosphorylation of key metabolic factors pathway
Integration of energy metabolism pathway
CREB phosphorylation through the activation of Adenylate Cyclase pathway
Signaling by FGFR in disease pathway
Transmembrane transport of small molecules pathway
Signalling by NGF pathway
Signaling by Hedgehog pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Metabolism of lipids and lipoproteins pathway
Myoclonic epilepsy of Lafora pathway
Neuronal System pathway
Signaling by VEGF pathway
Cytokine Signaling in Immune system pathway
Metabolism of carbohydrates pathway
Signaling by GPCR pathway
Innate Immune System pathway
Degradation of GLI2 by the proteasome pathway
GLI3 is processed to GLI3R by the proteasome pathway
Degradation of GLI1 by the proteasome pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
Post NMDA receptor activation events pathway
G-protein mediated events pathway
Cell Cycle pathway
Adaptive Immune System pathway
Immune System pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
Centrosome maturation pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
G2/M Transition pathway
Transmission across Chemical Synapses pathway
Cell Cycle, Mitotic pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Mitotic G2-G2/M phases pathway
Metabolism pathway
Lipid digestion, mobilization, and transport pathway
Ca-dependent events pathway
Aquaporin-mediated transport pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
Hemostasis pathway
Degradation of GLI1 by the proteasome pathway
G2/M Transition pathway
DAP12 interactions pathway
Aquaporin-mediated transport pathway
Signaling by EGFR pathway
PLCG1 events in ERBB2 signaling pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
Metabolism of carbohydrates pathway
Regulation of insulin secretion pathway
Factors involved in megakaryocyte development and platelet production pathway
PKA-mediated phosphorylation of CREB pathway
Signaling by GPCR pathway
Signaling by PDGF pathway
GLI3 is processed to GLI3R by the proteasome pathway
DARPP-32 events pathway
Calmodulin induced events pathway
DAG and IP3 signaling pathway
PLC-gamma1 signalling pathway
Signaling by FGFR pathway
Cytokine Signaling in Immune system pathway
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
Myoclonic epilepsy of Lafora pathway
Hemostasis pathway
Immune System pathway
Cell Cycle, Mitotic pathway
Loss of Nlp from mitotic centrosomes pathway
Integration of energy metabolism pathway
PKA-mediated phosphorylation of key metabolic factors pathway
EGFR interacts with phospholipase C-gamma pathway
Transmembrane transport of small molecules pathway
Mitotic G2-G2/M phases pathway
Signaling by ERBB2 pathway
Degradation of GLI2 by the proteasome pathway
Cell Cycle pathway
Signal Transduction pathway
Signaling by EGFR in Cancer pathway
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
Hedgehog 'off' state pathway
G-protein mediated events pathway
Metabolism of lipids and lipoproteins pathway
Gluconeogenesis pathway
Glycogen storage diseases pathway
NGF signalling via TRKA from the plasma membrane pathway
PLC beta mediated events pathway
Glucose metabolism pathway
Downstream signaling of activated FGFR pathway
Metabolism pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Signalling by NGF pathway
PKA activation pathway
Adaptive Immune System pathway
Signaling by Hedgehog pathway
Phospholipase C-mediated cascade pathway
PKA activation in glucagon signalling pathway
Downstream signal transduction pathway
Opioid Signalling pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Glucagon signaling in metabolic regulation pathway
Rap1 signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Centrosome maturation pathway
Innate Immune System pathway
Ca-dependent events pathway
CaM pathway pathway
Signaling by Interleukins pathway
DAP12 signaling pathway
Disease pathway
Signaling by FGFR in disease pathway
Lipid digestion, mobilization, and transport pathway
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| KEGG |
GnRH signaling pathway pathway
Vibrio cholerae infection pathway
Gap junction pathway
Wnt signaling pathway pathway
Olfactory transduction pathway
Hedgehog signaling pathway pathway
Apoptosis pathway
MAPK signaling pathway pathway
Long-term potentiation pathway
Insulin signaling pathway pathway
Taste transduction pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Parkinson's disease pathway
Vascular smooth muscle contraction pathway
Chemokine signaling pathway pathway
Prion diseases pathway
Progesterone-mediated oocyte maturation pathway
Dilated cardiomyopathy pathway
Vasopressin-regulated water reabsorption pathway
Oocyte meiosis pathway
Gastric acid secretion pathway
Amoebiasis pathway
Salivary secretion pathway
Bile secretion pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
VEGF signaling pathway pathway
GPCR Dopamine D1like receptor signaling pathway pathway
GPCR signaling pathway
Hedgehog signaling pathway pathway
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| PID NCI |
Syndecan-2-mediated signaling events
Calcium signaling in the CD4+ TCR pathway
Thromboxane A2 receptor signaling
Class I PI3K signaling events mediated by Akt
Aurora A signaling
Signaling events mediated by HDAC Class I
LKB1 signaling events
Retinoic acid receptors-mediated signaling
ErbB2/ErbB3 signaling events
Signaling events mediated by VEGFR1 and VEGFR2
Signaling events regulated by Ret tyrosine kinase
Alpha4 beta1 integrin signaling events
SHP2 signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Hedgehog signaling events mediated by Gli proteins
VEGFR1 specific signals
LPA4-mediated signaling events
Syndecan-1-mediated signaling events
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| Cross-References | |||||||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||
| UniGene | Mm.19111 Mm.410287 | ||||||||||||||||||||||||||||||||||
| RefSeq | NM_001277898 NM_008854 | ||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||
| CCDS | CCDS22463 | ||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||||||||||