InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sufu

Summary

InnateDB Gene

IDBG-173162.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sufu

Gene Name

suppressor of fused homolog (Drosophila)

Synonyms

Su(fu)

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025231

Encoded Proteins

IDBP-173164

suppressor of fused homolog (Drosophila)

IDBP-257215

suppressor of fused homolog (Drosophila)

IDBP-400941

suppressor of fused homolog (Drosophila)

IDBP-400942

suppressor of fused homolog (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107882:
The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:46396896-46488804

Strand

Forward strand

Band

Transcripts

ENSMUST00000039922	ENSMUSP00000049109
ENSMUST00000111867	ENSMUSP00000107498
ENSMUST00000118440	ENSMUSP00000113073
ENSMUST00000120778	ENSMUSP00000112653
ENSMUST00000123252
ENSMUST00000144341

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	40 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	5 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008134	transcription factor binding
GO:0019901	protein kinase binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001843	neural tube closure
GO:0001947	heart looping
GO:0007368	determination of left/right symmetry
GO:0021513	spinal cord dorsal/ventral patterning
GO:0021775	smoothened signaling pathway involved in ventral spinal cord interneuron specification
GO:0021776	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
GO:0042994	cytoplasmic sequestering of transcription factor
GO:0043588	skin development
GO:0045879	negative regulation of smoothened signaling pathway
GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process