InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Eif5

Summary

InnateDB Gene

IDBG-173165.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif5

Gene Name

eukaryotic translation initiation factor 5

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021282

Encoded Proteins

IDBP-173167

eukaryotic translation initiation factor 5

IDBP-623423

eukaryotic translation initiation factor 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100664:
Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:111538101-111546753

Strand

Forward strand

Band

Transcripts

ENSMUST00000050993	ENSMUSP00000061616
ENSMUST00000166123	ENSMUSP00000126825

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0044822	poly(A) RNA binding