Mus musculus Gene: Mcl1
Summary
InnateDB Gene IDBG-173221.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mcl1
Gene Name myeloid cell leukemia sequence 1
Synonyms AW556805; Mcl-1;
Species Mus musculus
Ensembl Gene ENSMUSG00000038612
Encoded Proteins
myeloid cell leukemia sequence 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143384:
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:95658721-95663176
Strand Forward strand
Band F2.1
Transcripts
ENSMUST00000037947 ENSMUSP00000044048
ENSMUST00000178686 ENSMUSP00000135915
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 35 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0051434 BH3 domain binding
Biological Process
GO:0007275 multicellular organismal development
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008637 apoptotic mitochondrial changes
GO:0030154 cell differentiation
GO:0034097 response to cytokine
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097194 execution phase of apoptosis
GO:2000811 negative regulation of anoikis
GO:2001020 regulation of response to DNA damage stimulus
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0097136 Bcl-2 family protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Direct p53 effectors
E2F transcription factor network
HIF-1-alpha transcription factor network
IL6-mediated signaling events
Cross-References
SwissProt P97287
TrEMBL
UniProt Splice Variant
Entrez Gene 17210
UniGene Mm.1639 Mm.413637 Mm.466578
RefSeq NM_008562
OMIM
CCDS CCDS57236
HPRD
IMGT
MGI ID MGI:101769
MGI Symbol Mcl1
EMBL AC092479 AF063886 AK010424 AK159504 AK160594 BC003839 BC005427 BC021638 FO082281 GU182318 U35623
GenPept AAC27929 AAC31790 AAH03839 AAH05427 AAH21638 ACZ54910 BAB26927 BAE35137 BAE35901
RNA Seq Atlas 17210