Homo sapiens Gene: TEC
Summary
InnateDB Gene IDBG-17328.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TEC
Gene Name tec protein tyrosine kinase
Synonyms PSCTK4;
Species Homo sapiens
Ensembl Gene ENSG00000135605
Encoded Proteins
tec protein tyrosine kinase
tec protein tyrosine kinase
tec protein tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:48135783-48269864
Strand Reverse strand
Band p11
Transcripts
ENST00000381501 ENSP00000370912
ENST00000505452 ENSP00000424567
ENST00000515146 ENSP00000424365
ENST00000511150
ENST00000511471
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 4 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008289 lipid binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007229 integrin-mediated signaling pathway
GO:0010543 regulation of platelet activation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042246 tissue regeneration
GO:0045087 innate immune response
GO:0050853 B cell receptor signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
KitReceptor pathway
TCR pathway
BCR pathway
IL3 pathway
IL6 pathway
TSLP pathway
Prolactin pathway
REACTOME
Interleukin-3, 5 and GM-CSF signaling pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Immune System pathway
Signaling by Interleukins pathway
FCERI mediated Ca+2 mobilization pathway
KEGG
Osteoclast differentiation pathway
T cell receptor signaling pathway pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
EPO signaling pathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Cross-References
SwissProt
TrEMBL D6RB75
UniProt Splice Variant
Entrez Gene 7006
UniGene Hs.479670
RefSeq NM_003215 XM_005248123 XM_006714027
HUGO HGNC:11719
OMIM 600583
CCDS CCDS3481
HPRD
IMGT
EMBL AC079118 AC098873
GenPept
RNA Seq Atlas 7006