InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ndufs7

Summary

InnateDB Gene

IDBG-173377.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndufs7

Gene Name

NADH dehydrogenase (ubiquinone) Fe-S protein 7

Synonyms

1010001M04Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020153

Encoded Proteins

IDBP-173379

NADH dehydrogenase (ubiquinone) Fe-S protein 7

IDBP-271033

NADH dehydrogenase (ubiquinone) Fe-S protein 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115286:
This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic lesions in subcortical brain regions. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:80249121-80256794

Strand

Forward strand

Band

Transcripts

ENSMUST00000020361	ENSMUSP00000020361
ENSMUST00000105364	ENSMUSP00000101003
ENSMUST00000152939
ENSMUST00000155523
ENSMUST00000157063
ENSMUST00000155336

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0003954	NADH dehydrogenase activity
GO:0005515	protein binding
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0046872	metal ion binding
GO:0048038	quinone binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0032981	mitochondrial respiratory chain complex I assembly
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005747	mitochondrial respiratory chain complex I
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0097060	synaptic membrane