InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SMG1

Summary

InnateDB Gene

IDBG-17338.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMG1

Gene Name

smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)

Synonyms

61E3.4; ATX; LIP

Species

Homo sapiens

Ensembl Gene

ENSG00000157106

Encoded Proteins

IDBP-371126

smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)

IDBP-598317

smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)

IDBP-747954

IDBP-749172

IDBP-748540

IDBP-745442

IDBP-750512

IDBP-751587

IDBP-746366

IDBP-809328

SMG1 phosphatidylinositol 3-kinase-related kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:18804853-18926454

Strand

Reverse strand

Band

p12.3

Transcripts

ENST00000446231	ENSP00000402515
ENST00000532700	ENSP00000432825
ENST00000562668
ENST00000565324	ENSP00000456259
ENST00000561947	ENSP00000460854
ENST00000567737
ENST00000568038	ENSP00000458558
ENST00000561940
ENST00000563235	ENSP00000455861
ENST00000563836	ENSP00000456025
ENST00000563448
ENST00000569122	ENSP00000455453
ENST00000568239
ENST00000565224	ENSP00000458380
ENST00000569764
ENST00000566328	ENSP00000484278

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006281	DNA repair
GO:0006406	mRNA export from nucleus
GO:0006950	response to stress
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0046777	protein autophosphorylation
GO:0046854	phosphatidylinositol phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030655

View Gene Order

ENSBTAG00000020735

Not yet available

Pathways

NETPATH

REACTOME

REACT_75822

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway

REACT_75886

Nonsense-Mediated Decay (NMD) pathway

REACT_71

Gene Expression pathway

KEGG

hsa03015

mRNA surveillance pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.460179 Hs.602626 Hs.622357 Hs.636317 Hs.654650 Hs.733481

RefSeq

NM_015092 XM_005255185

HUGO

OMIM

CCDS

CCDS45430

HPRD

06123

IMGT

EMBL

GenPept

RNA Seq Atlas