Version 5.4
Mus musculus Gene: Tiam1
Summary
InnateDB Gene IDBG-174466.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tiam1
Gene Name T cell lymphoma invasion and metastasis 1
Synonyms AI847750; D16Ium10; D16Ium10e
Species Mus musculus
Ensembl Gene ENSMUSG00000002489
Encoded Proteins
IDBP-174470
T-cell lymphoma invasion and metastasis 1
IDBP-252404
T-cell lymphoma invasion and metastasis 1
IDBP-252406
T-cell lymphoma invasion and metastasis 1
IDBP-707662
IDBP-707192
IDBP-625335
T-cell lymphoma invasion and metastasis 1
IDBP-625337
T-cell lymphoma invasion and metastasis 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156299:
Gene Information
Type Protein coding
Genomic Location Chromosome 16:89787111-89980080
Strand Reverse strand
Band C3.3
Transcripts
ENSMUST00000089084
ENSMUST00000002588 ENSMUSP00000002588
ENSMUST00000114124 ENSMUSP00000109759
ENSMUST00000114122 ENSMUSP00000109757
ENSMUST00000144691 ENSMUSP00000136283
ENSMUST00000134021 ENSMUSP00000137637
ENSMUST00000151655
ENSMUST00000130951
ENSMUST00000139544
ENSMUST00000124433
ENSMUST00000155915
ENSMUST00000136760
ENSMUST00000163370 ENSMUSP00000132137
ENSMUST00000164263 ENSMUSP00000126020
ENSMUST00000178095
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0030676 Rac guanyl-nucleotide exchange factor activity
GO:0046875 ephrin receptor binding
Biological Process
GO:0007160 cell-matrix adhesion
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0016477 cell migration
GO:0016601 Rac protein signal transduction
GO:0032314 regulation of Rac GTPase activity
GO:0032319 regulation of Rho GTPase activity
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0043087 regulation of GTPase activity
GO:0048013 ephrin receptor signaling pathway
GO:0050772 positive regulation of axonogenesis
Cellular Component
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0044291 cell-cell contact zone
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000156299
View Gene Order
ENSBTAG00000017839
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04810
Regulation of actin cytoskeleton pathway
mmu04062
Chemokine signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_18266
Axon guidance pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_228170
EPH-Ephrin signaling pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04062
Chemokine signaling pathway pathway
INOH
PID NCI
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
rac1_reg_pathway
Regulation of RAC1 activity
lysophospholipid_pathway
LPA receptor mediated events
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
ephrinbrevpathway
Ephrin B reverse signaling
cdc42_pathway
CDC42 signaling events
arf6downstreampathway
Arf6 downstream pathway
epha2_fwdpathway
EPHA2 forward signaling
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL E9Q1R7 E9Q2Y4 G3UWG2 J3QMH1 Q3UHH6
UniProt Splice Variant
Entrez Gene 21844
UniGene Mm.310902 Mm.418562
RefSeq NM_001145886 NM_001145887 NM_009384 XM_006522978 XM_006522979 XM_006522980 XM_006522981 XM_006522982 XM_006522983
OMIM
CCDS CCDS28314 CCDS49904
HPRD
IMGT
MGI ID MGI:103306
MGI Symbol Tiam1
EMBL AC087840 AC102908 AC122218 AK147392 CH466521
GenPept BAE27881 EDK98383
RNA Seq Atlas 21844

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca