InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sod1

Summary

InnateDB Gene

IDBG-174662.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sod1

Gene Name

superoxide dismutase 1, soluble

Synonyms

B430204E11Rik; Cu/Zn-SOD; CuZnSOD; Ipo-1; Ipo1; Sod-1; SODC

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022982

Encoded Proteins

IDBP-174664

superoxide dismutase 1, soluble

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26588782

Sod1 is essential in protecting hepatocytes from virus-induced, interferon-driven oxidative damage in the liver.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142168:
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:90220742-90226322

Strand

Forward strand

Band

C3.3

Transcripts

ENSMUST00000023707

ENSMUSP00000023707

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004784	superoxide dismutase activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0030346	protein phosphatase 2B binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0048365	Rac GTPase binding
GO:0051087	chaperone binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0000302	response to reactive oxygen species
GO:0000303	response to superoxide
GO:0001541	ovarian follicle development
GO:0001819	positive regulation of cytokine production
GO:0001895	retina homeostasis
GO:0001975	response to amphetamine
GO:0002262	myeloid cell homeostasis
GO:0006749	glutathione metabolic process
GO:0006801	superoxide metabolic process
GO:0006879	cellular iron ion homeostasis
GO:0006979	response to oxidative stress
GO:0007283	spermatogenesis
GO:0007566	embryo implantation
GO:0007568	aging
GO:0007569	cell aging
GO:0007605	sensory perception of sound
GO:0007626	locomotory behavior
GO:0008089	anterograde axon cargo transport
GO:0008090	retrograde axon cargo transport
GO:0008217	regulation of blood pressure
GO:0009408	response to heat
GO:0010033	response to organic substance
GO:0019226	transmission of nerve impulse
GO:0019430	removal of superoxide radicals
GO:0031667	response to nutrient levels
GO:0032287	peripheral nervous system myelin maintenance
GO:0032314	regulation of Rac GTPase activity
GO:0032930	positive regulation of superoxide anion generation
GO:0034465	response to carbon monoxide
GO:0034599	cellular response to oxidative stress
GO:0035865	cellular response to potassium ion
GO:0040014	regulation of multicellular organism growth
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0042554	superoxide anion generation
GO:0043066	negative regulation of apoptotic process
GO:0043085	positive regulation of catalytic activity
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0045541	negative regulation of cholesterol biosynthetic process
GO:0045859	regulation of protein kinase activity
GO:0046677	response to antibiotic
GO:0046688	response to copper ion
GO:0046716	muscle cell cellular homeostasis
GO:0048678	response to axon injury
GO:0050665	hydrogen peroxide biosynthetic process
GO:0051881	regulation of mitochondrial membrane potential
GO:0055114	oxidation-reduction process
GO:0060047	heart contraction
GO:0060052	neurofilament cytoskeleton organization
GO:0060087	relaxation of vascular smooth muscle
GO:0060088	auditory receptor cell stereocilium organization
GO:0071276	cellular response to cadmium ion
GO:0071318	cellular response to ATP
GO:0072593	reactive oxygen species metabolic process
GO:0097332	response to antipsychotic drug
GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0005777	peroxisome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030141	secretory granule
GO:0031012	extracellular matrix
GO:0031045	dense core granule
GO:0031410	cytoplasmic vesicle
GO:0032839	dendrite cytoplasm
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome