Version 5.4
Mus musculus Gene: Edem1
Summary
InnateDB Gene IDBG-174709.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Edem1
Gene Name ER degradation enhancer, mannosidase alpha-like 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000030104
Encoded Proteins
IDBP-174711
ER degradation enhancer, mannosidase alpha-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134109:
Gene Information
Type Protein coding
Genomic Location Chromosome 6:108828641-108859356
Strand Forward strand
Band E2
Transcripts
ENSMUST00000089162 ENSMUSP00000086565
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0051787 misfolded protein binding
Biological Process
GO:0006986 response to unfolded protein
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0016020 membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134109
View Gene Order
ENSBTAG00000012904
Not yet available
Pathways
NETPATH
REACTOME
REACT_239697
Unfolded Protein Response (UPR) pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_231085
IRE1alpha activates chaperones pathway
REACT_237472
Asparagine N-linked glycosylation pathway
REACT_198606
ER Quality Control Compartment (ERQC) pathway
REACT_106572
XBP1(S) activates chaperone genes pathway
REACT_198618
N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway
REACT_198616
Calnexin/calreticulin cycle pathway
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25091
ER Quality Control Compartment (ERQC) pathway
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_23810
Calnexin/calreticulin cycle pathway
REACT_23878
N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.21596
RefSeq NM_138677 XM_006505746
OMIM
CCDS CCDS20402
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca