Homo sapiens Gene: SCT
Summary
InnateDB Gene IDBG-17495.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCT
Gene Name secretin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000070031
Encoded Proteins
secretin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Secretin belongs to the glucagon family. This protein is an endocrine hormone and its major site of production is the endocrine S cells located in the proximal small intestinal mucosa. The release of active secretin is stimulated by either fatty acids or an acidic pH in the duodenum. This hormone stimulates the secretion of bicarbonate-rich pancreatic fluids and has also been shown to regulate the growth and development of the stomach, small intestine, and pancreas. Secretin deficiency has been implicated in autistic syndrome, suggesting that the hormone could have a neuroendocrine function in addition to its role in digestion. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:626431-627143
Strand Reverse strand
Band p15.5
Transcripts
ENST00000176195 ENSP00000176195
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
Biological Process
GO:0008542 visual learning
GO:0021542 dentate gyrus development
GO:0030157 pancreatic juice secretion
GO:0043524 negative regulation of neuron apoptotic process
GO:0097150 neuronal stem cell maintenance
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Glucagon-type ligand receptors pathway
GPCR ligand binding pathway
Class B/2 (Secretin family receptors) pathway
KEGG
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P09683
TrEMBL
UniProt Splice Variant
Entrez Gene 6343
UniGene Hs.632324
RefSeq NM_021920
HUGO HGNC:10607
OMIM 182099
CCDS CCDS7709
HPRD 08354
IMGT
EMBL AF244355
GenPept AAG31443
RNA Seq Atlas 6343