InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fcgr1

Summary

InnateDB Gene

IDBG-175237.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fcgr1

Gene Name

Fc receptor, IgG, high affinity I

Synonyms

AI323638; AV092959; CD64; FcgammaRI; IGGHAFC

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015947

Encoded Proteins

IDBP-175239

Fc receptor, IgG, high affinity I

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21044955

[Homo sapiens] FCGR1A (FcgammaRI) is a receptor that recognizes IgG opsonized particles and initiates phagocytosis in immune clearance. FCGR1A is also a negative regulator of complement-mediated phagocytosis.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150337:
Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene encodes the low affinity FcgammaRIB receptor that may play an important role in humoral immune response. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011] This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]
This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:96282909-96293969

Strand

Reverse strand

Band

F2.1

Transcripts

ENSMUST00000029748

ENSMUSP00000029748

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019770	IgG receptor activity
GO:0019864	IgG binding

Biological Process

GO:0001788	antibody-dependent cellular cytotoxicity
GO:0001798	positive regulation of type IIa hypersensitivity
GO:0001805	positive regulation of type III hypersensitivity
GO:0006898	receptor-mediated endocytosis
GO:0006910	phagocytosis, recognition
GO:0006911	phagocytosis, engulfment
GO:0007166	cell surface receptor signaling pathway
GO:0009617	response to bacterium
GO:0019884	antigen processing and presentation of exogenous antigen
GO:0038094	Fc-gamma receptor signaling pathway
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042742	defense response to bacterium
GO:0045087	innate immune response
GO:0050766	positive regulation of phagocytosis
GO:0050776	regulation of immune response